Osteoarthritis and cardiovascular disease: A Mendelian randomization study

Zhao Wang; Chan Kang; Pai Xu; Shuyi Zhang; Jae Hwang Song; Dongyang Wang; Shuai Yuan; Hyun Jong Lee; Meng Zhang; Zhihui Wang; Hao Sun; Ruobing Fan

doi:10.3389/fcvm.2022.1025063

Osteoarthritis and cardiovascular disease: A Mendelian randomization study

Front Cardiovasc Med. 2022 Nov 18:9:1025063. doi: 10.3389/fcvm.2022.1025063. eCollection 2022.

Authors

Zhao Wang¹, Chan Kang¹, Pai Xu¹, Shuyi Zhang², Jae Hwang Song³, Dongyang Wang⁴, Shuai Yuan⁵, Hyun Jong Lee¹, Meng Zhang⁶, Zhihui Wang⁶, Hao Sun⁶, Ruobing Fan⁷

Affiliations

¹ Department of Orthopedic Surgery, Chungnam National University School of Medicine, Daejeon, South Korea.
² Department of Orthopedic Surgery, The Second Hospital of Fuzhou Affiliated to Xiamen University, Fuzhou, China.
³ Department of Orthopedic Surgery, Konyang University Hospital, Daejeon, South Korea.
⁴ School of Nursing, Binzhou Medical University, Yantai, China.
⁵ Departmentof Surgery, School of Medicine, Ajou University, Suwon, South Korea.
⁶ Affiliated Hospital of Chengde Medical University, Chengde, China.
⁷ Graduate School of Hebei Medical University, Shijiazhuang, China.

Abstract

Objective: This Mendelian randomization (MR) study aimed to investigate the causal relationship between osteoarthritis (OA) and cardiovascular disease (CVD).

Methods: From a genome-wide association study of European ancestry, we selected single nucleotide polymorphisms for two types of OA, knee osteoarthritis (KOA) and hip osteoarthritis (HOA), as instrumental variables. We evaluated three types of CVD: coronary heart disease (CHD), heart failure (HF), and stroke. We used the traditional inverse variance weighting (IVW) method and other methods to estimate causality. Heterogeneity and sensitivity tests were also applied. Finally, we conducted a MR analysis in the opposite direction to investigate reverse causality.

Results: IVW analysis showed that HOA significantly affected the incidence of HF [odds ratio (OR): 1.0675; 95% confidence interval (CI): 0.0182-0.1125, P = 0.0066]. HOA significantly affected the incidence of stroke (OR: 1.1368; 95% CI: 1.0739-1.2033, P = 9.9488e-06). CHD could dramatically affect the incidence of KOA (OR: 0.9011; 95% CI: 0.8442-0.9619, P = 0.0018). The rest of the results were negative.

Conclusions: Our results revealed a potential causal relationship between HOA and risk of HF, and a potential causal relationship between HOA and risk of stroke. Our findings also suggested that CHD has a significant causal relationship with the risk of KOA. This paper may provide new ideas for the treatment of OA and CVD.

Keywords: Coronary heart disease (CHD); Mendelian randomization (MR); heart failure; hip osteoarthritis (HOA); knee osteoarthritis (KOA); stroke.