Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease

Mary M Kavurma; Christina Bursill; Christopher P Stanley; Freda Passam; Siân P Cartland; Sanjay Patel; Jacky Loa; Gemma A Figtree; Jonathan Golledge; Sarah Aitken; David A Robinson

doi:10.3389/fcvm.2022.1054576

Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease

Front Cardiovasc Med. 2022 Nov 16:9:1054576. doi: 10.3389/fcvm.2022.1054576. eCollection 2022.

Authors

Mary M Kavurma¹, Christina Bursill^{2

3}, Christopher P Stanley¹, Freda Passam^{1

4}, Siân P Cartland¹, Sanjay Patel^{1

5}, Jacky Loa⁵, Gemma A Figtree^{6

7}, Jonathan Golledge^{8

9}, Sarah Aitken^{6

10}, David A Robinson⁵

Affiliations

¹ Heart Research Institute, The University of Sydney, Sydney, NSW, Australia.
² South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
³ Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.
⁴ Central Clinical School, Faculty of Health and Medicine, The University of Sydney, Sydney, NSW, Australia.
⁵ Royal Prince Alfred Hospital, Sydney, NSW, Australia.
⁶ Faculty of Health and Medicine, The University of Sydney, Sydney, NSW, Australia.
⁷ Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, NSW, Australia.
⁸ Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.
⁹ The Department of Vascular and Endovascular Surgery, Townsville University Hospital, Townsville, QLD, Australia.
¹⁰ Concord Institute of Academic Surgery, Concord Hospital, Sydney, NSW, Australia.

Abstract

Peripheral artery disease (PAD) is caused by occluded or narrowed arteries that reduce blood flow to the lower limbs. The treatment focuses on lifestyle changes, management of modifiable risk factors and vascular surgery. In this review we focus on how Endothelial Cell (EC) dysfunction contributes to PAD pathophysiology and describe the largely untapped potential of correcting endothelial dysfunction. Moreover, we describe current treatments and clinical trials which improve EC dysfunction and offer insights into where future research efforts could be made. Endothelial dysfunction could represent a target for PAD therapy.

Keywords: angiogenesis; endothelial cell dysfunction; inflammation; peripheral artery disease (PAD); therapeutics; thrombosis; vascular tone.

Publication types

Review