We demonstrate a mirror position actuator that operates in a wide temperature range from room temperature to a deep cryogenic regime (10 K). We use a Michelson interferometer to measure the actuator tuning range (and piezoelectric efficiency) in the full temperature range. We demonstrate an unprecedented range of tunability of the mirror position in the cryogenic regime (over 22 μm at 10 K). The capability of controlling the mirror position in the range from few to few tens of microns is crucial for cavity-enhanced molecular spectroscopy techniques, especially in the important mid-infrared spectral regime where the length of an optical cavity has to be tunable in a range larger than the laser wavelength. The piezoelectric actuator offering this range of tunability in the cryogenic conditions, on the one hand, will enable development of optical cavities operating at low temperatures that are crucial for spectroscopy of large molecules whose dense spectra are difficult to resolve at room temperature. On the other hand, this will enable us to increase the accuracy of the measurement of simple molecules aimed at fundamental studies.