Advanced Cell Therapy: Beyond the last Frontier in the Treatment of Cancer. A Historical Perspective Emphasizing the Work of Nobel Prize Laureates

Arch Med Res. 2022 Dec;53(8):747-752. doi: 10.1016/j.arcmed.2022.11.006. Epub 2022 Nov 29.

Abstract

During the last five decades different therapies have been developed for the treatment of cancer, and as a result, patients can now live longer and better lives. Among such therapies, hematopoietic cell transplantation and immunotherapy have played key roles. In this short article, we present our particular point of view on the development of these two cellular therapies. We have focused on a historical perspective emphasizing the work of some of the Nobel Prize winners whose studies constituted cornerstones in our knowledge of the biology of cancer and in our fight against this devastating disease.

Keywords: CAR cells; Cancer; Cell Therapy; MHC, Transplants.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Cell- and Tissue-Based Therapy
  • Hematopoietic Stem Cell Transplantation*
  • History, 20th Century
  • Humans
  • Immunotherapy
  • Neoplasms* / therapy
  • Nobel Prize