Sustained neural representations of personally familiar people and places during cued recall

Abstract

The recall and visualization of people and places from memory is an everyday occurrence, yet the neural mechanisms underpinning this phenomenon are not well understood. In particular, the temporal characteristics of the internal representations generated by active recall are unclear. Here, we used magnetoencephalography (MEG) and multivariate pattern analysis to measure the evolving neural representation of familiar places and people across the whole brain when human participants engage in active recall. To isolate self-generated imagined representations, we used a retro-cue paradigm in which participants were first presented with two possible labels before being cued to recall either the first or second item. We collected personalized labels for specific locations and people familiar to each participant. Importantly, no visual stimuli were presented during the recall period, and the retro-cue paradigm allowed the dissociation of responses associated with the labels from those corresponding to the self-generated representations. First, we found that following the retro-cue it took on average ∼1000 ms for distinct neural representations of freely recalled people or places to develop. Second, we found distinct representations of personally familiar concepts throughout the 4 s recall period. Finally, we found that these representations were highly stable and generalizable across time. These results suggest that self-generated visualizations and recall of familiar places and people are subserved by a stable neural mechanism that operates relatively slowly when under conscious control.

Keywords: Magnetoencephalography; Multivariate decoding; Neural representations; Recall; Temporal dynamics.