Divergent Actions of Myofibroblast and Myocyte β2-Adrenoceptor in Heart Failure and Fibrotic Remodeling

Bingqing Deng; Yu Zhang; Chaoqun Zhu; Ying Wang; Eric Weatherford; Bing Xu; Xianhui Liu; Simon J Conway; E. Dale Abel; Yang K Xiang

doi:10.1161/CIRCRESAHA.122.321816

Divergent Actions of Myofibroblast and Myocyte β₂-Adrenoceptor in Heart Failure and Fibrotic Remodeling

Circ Res. 2023 Jan 6;132(1):106-108. doi: 10.1161/CIRCRESAHA.122.321816. Epub 2022 Dec 2.

Authors

Bingqing Deng^#¹, Yu Zhang^#¹, Chaoqun Zhu^#¹, Ying Wang¹, Eric Weatherford², Bing Xu^{1

3}, Xianhui Liu¹, Simon J Conway⁴, E. Dale Abel^{2

5}, Yang K Xiang^{1

3}

Affiliations

¹ Department of Pharmacology, University of California at Davis (B.D., Y.Z., C.Z., Y.W., B.X., X.L., Y.K.X.).
² Fraternal Order of Eagles Diabetes Research Center and Department of Medicine, University of Iowa, Iowa City (E.W., E.D.A.).
³ VA Northern California, Mather (B.X., Y.K.X.).
⁴ Department of Pediatrics, Indiana University School of Medicine (S.J.C.).
⁵ Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA (E.D.A.).

^# Contributed equally.

No abstract available

Keywords: cardiomyopathies; connective tissue growth factor; extracellular matrix heart failure; myofibroblasts; stroke volume; transforming growth factors.

Publication types

Letter
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Extracellular Matrix
Fibroblasts
Fibrosis
Heart Failure* / pathology
Humans
Myocardium
Myofibroblasts* / pathology
Receptors, Adrenergic
Transforming Growth Factor beta1

Substances

Receptors, Adrenergic
Transforming Growth Factor beta1

Publication types

MeSH terms

Substances

Grants and funding