On the horizon: Extracorporeal carbon dioxide removal

Justin Hanks; Steven Fox; Omar Mehkri; Laura W Lund; Tracey Dill; Abhijit Duggal; Sudhir Krishnan

doi:10.3949/ccjm.89a.21084

On the horizon: Extracorporeal carbon dioxide removal

Cleve Clin J Med. 2022 Dec 1;89(12):712-718. doi: 10.3949/ccjm.89a.21084.

Authors

Justin Hanks¹, Steven Fox², Omar Mehkri³, Laura W Lund⁴, Tracey Dill⁵, Abhijit Duggal⁶, Sudhir Krishnan⁷

Affiliations

¹ Pulmonary and Critical Care Fellowship, Respiratory Institute, Cleveland Clinic, Cleveland, OH hanksj@ccf.org.
² Assistant Professor, Division of Pulmonary, Allergy, and Critical Care, University of Alabama, Birmingham, AL.
³ Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH.
⁴ Consultant at Lund MDC, Pittsburgh, PA.
⁵ Vice-President of Clinical Operations, ALung Technologies Inc., Pittsburgh, PA.
⁶ Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH; Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
⁷ Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.

PMID: 36455974
DOI: 10.3949/ccjm.89a.21084

Abstract

Extracorporeal carbon dioxide removal (ECCO₂R) uses mechanical systems to treat hypercapnic respiratory failure. Its utility has been investigated in acute respiratory distress syndrome (ARDS), acute exacerbations of chronic obstructive pulmonary disease (COPD), and status asthmaticus, and as a bridge to lung transplant. In this review, we discuss how it works, why it should help, and current evidence supporting its use.

Publication types

Review

MeSH terms

Carbon Dioxide
Humans
Lung Transplantation*
Renal Dialysis
Respiratory Distress Syndrome* / therapy
Respiratory Insufficiency* / therapy

Substances

Carbon Dioxide