The French version of the Gilles de la Tourette Syndrome Quality of Life Scale for adolescents (GTS-QOL-French-Ado): Adaptation and psychometric evaluation

Isabelle Jalenques; Candy Guiguet-Auclair; Diane Cyrille; Clement Debosque; Philippe Derost; Andreas Hartmann; Sophie Lauron; Clara Jameux; Urbain Tauveron-Jalenques; Fabien Rondepierre; Syndrome de Gilles de La Tourette Study Group

doi:10.1371/journal.pone.0278383

The French version of the Gilles de la Tourette Syndrome Quality of Life Scale for adolescents (GTS-QOL-French-Ado): Adaptation and psychometric evaluation

PLoS One. 2022 Nov 30;17(11):e0278383. doi: 10.1371/journal.pone.0278383. eCollection 2022.

Affiliations

¹ Service de Psychiatrie de l'Adulte A et Psychologie Médicale, Centre de Compétence Gilles de la Tourette, CNRS, Institut Pascal, CHU Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France.
² CNRS, Institut Pascal, CHU Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France.
³ Service de Psychiatrie de l'Adulte A et Psychologie Médicale, CNRS, Institut Pascal, CHU Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France.
⁴ Service de Neurologie, CHU Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France.
⁵ Department of Neurology, National Reference Center for Tourette Syndrome, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

Abstract

Introduction: The aim of this study was to create a new version of the French GTS-QOL adapted to adolescents with GTS aged 12-16 years (GTS-QOL-French-Ado) and to evaluate its psychometric properties.

Methods: We assessed the psychometric properties of the GTS-QOL-French-Ado in 84 adolescents (mean age 13.6 years, standard deviation 1.2) in terms of factor structure, internal consistency, reliability and convergent validity with the Child Depression Inventory (CDI), the Multidimensional Anxiety Scale for Children (MASC), the Motor tic, Obsessions and compulsions, Vocal tic Evaluation Survey (MOVES) and the French "Vécu et Santé Perçue de l'Adolescent" (VSP-A), a generic self-administered measure of health-related quality of life (HRQoL) in adolescents.

Results: Exploratory factor analysis of the GTS-QOL-French-Ado resulted in a 5-factor solution. The GTS-QOL-French-Ado demonstrated good acceptability with missing values per subscale ranging from 0% to 1.2%, good internal consistency for four of the five subscales with Cronbach's alpha ranging from 0.56 to 0.87 and good test-retest reliability with intraclass correlation coefficients ranging from 0.74 (95% CI: 0.52-0.86) to 0.82 (95% CI: 0.66-0.91). Convergent validity was supported by correlations with CDI, MASC, MOVES, VSP-A and clinical variables.

Discussion: The GTS-QOL-French-Ado is the first disease-specific HRQoL tool for French-speaking adolescents with GTS aged 12-16 years, and shows good psychometric properties. Further psychometric testing on responsiveness to change would be of great interest.

Copyright: © 2022 Jalenques et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acclimatization
Adolescent
Child
Humans
Psychometrics
Quality of Life*
Reproducibility of Results
Tourette Syndrome* / diagnosis

Grants and funding

IJ received a grant from the University Hospital of Clermont-Ferrand (AOI 2012) and the Association Française Syndrome Gilles de la Tourette (AO AFSGT 2015). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.