Persistent isolated impairment of gas transfer following COVID-19 pneumonitis relates to perfusion defects on dual-energy computed tomography

Laura C Price; Benjamin Garfield; Chloe Bloom; Nidhish Jeyin; Daniel Nissan; James H Hull; Brijesh Patel; Gisli Jenkins; Simon Padley; William Man; Suveer Singh; Carole A Ridge

doi:10.1183/23120541.00224-2022

Persistent isolated impairment of gas transfer following COVID-19 pneumonitis relates to perfusion defects on dual-energy computed tomography

ERJ Open Res. 2022 Nov 28;8(4):00224-2022. doi: 10.1183/23120541.00224-2022. eCollection 2022 Oct.

Authors

Laura C Price^{1

2}, Benjamin Garfield^{2

3}, Chloe Bloom², Nidhish Jeyin⁴, Daniel Nissan⁵, James H Hull⁶, Brijesh Patel⁷, Gisli Jenkins^{2

6}, Simon Padley^{2

8}, William Man⁹, Suveer Singh^{2

3}, Carole A Ridge^{2

8}

Affiliations

¹ National Pulmonary Hypertension Service, Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.
² National Heart and Lung Institute, Imperial College London, London, UK.
³ Department of Adult Intensive Care, Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.
⁴ Imperial College School of Medicine, London, UK.
⁵ Dept of Cardiology, Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.
⁶ Dept of Respiratory Medicine, Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.
⁷ Division of Anaesthetics, Pain Medicine, and Intensive Care, Department of Surgery and Cancer, Imperial College London, London, UK.
⁸ Department of Radiology, Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.
⁹ Harefield Respiratory Research Group, Royal Brompton & Harefield Clinical Group, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Abstract

A novel iodine perfusion score correlates with breathlessness and D _LCO in patients post-#COVID19 without obvious interstitial disease on CT, suggesting that lung perfusion assessment may be useful in patients without another cause of dyspnoea https://bit.ly/3U6E2f5.