Transmissible spongiform encephalopathies (TSEs) or prion diseases consist of a broad range of fatal neurological disorders affecting humans and animals. Contrary to Watson and Crick's 'central dogma', prion diseases are caused by a protein, devoid of DNA involvement. Herein, we briefly review various cellular and biological aspects of prions and prion pathogenesis focusing mainly on historical milestones, biosynthesis, degradation, structure-function of cellular and scrapie forms of prions .
Keywords: Cell death, Signal; Neurotoxicity; Prion protein; Protein biochemistry; Protein quality control; Transduction, Protein degradation.
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.