RNA Modifications Meet Tumors

Zhiyuan Yang; Siyu Zhang; Tian Xia; Yue Fan; Ying Shan; Kaiwen Zhang; Jiayan Xiong; Miao Gu; Bo You

doi:10.2147/CMAR.S391067

RNA Modifications Meet Tumors

Cancer Manag Res. 2022 Nov 22:14:3223-3243. doi: 10.2147/CMAR.S391067. eCollection 2022.

Authors

Zhiyuan Yang^#^{1

2}, Siyu Zhang^#^{1

2}, Tian Xia^#^{1

2}, Yue Fan^{1

2}, Ying Shan^{1

2}, Kaiwen Zhang^{1

2}, Jiayan Xiong^{1

2}, Miao Gu^{1

2}, Bo You^{1

2}

Affiliations

¹ Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, People's Republic of China.
² Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, People's Republic of China.

^# Contributed equally.

Abstract

RNA modifications occur through the whole process of gene expression regulation, including transcription, translation, and post-translational processes. They are closely associated with gene expression, RNA stability, and cell cycle. RNA modifications in tumor cells play a vital role in tumor development and metastasis, changes in the tumor microenvironment, drug resistance in tumors, construction of tumor cell-cell "internet", etc. Several types of RNA modifications have been identified to date and have various effects on the biological characteristics of different tumors. In this review, we discussed the function of RNA modifications, including N ⁶-methyladenine (m⁶A), 5-methylcytosine (m⁵C), N ⁷-methyladenosine (m⁷G), N ¹-methyladenosine (m¹A), pseudouridine (Ψ), and adenosine-to-inosine (A-to-I), in the microenvironment and therapy of solid and liquid tumors.

Keywords: RNA modification; non-coding RNA; tumor; tumor microenvironment; tumor therapy.

Publication types

Review

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (82173288, 81972554, 81672682, and 81602385), Natural Science Foundation of Jiangsu (No. BK20201208), Clinical Frontier Technology of Jiangsu (BE2017680), CSCO Clinical Oncology Research Foundation of Beijing (Y-HS2017-074, Y-HS2017-074), Innovative Research Project for Postgraduate Students in Jiangsu Province (SJCX19_0871, SJCX19_0872, SJCX20_1164), and the Scientific Research Project of Nantong Municipal Health Commission (QA2019060).