Children And Adolescents With Irritable Bowel Syndrome: Treatment And Management

Ankita Wal; Pranay Wal; Neha Verma; Shiv Shanker Pandey; Karthickeyan Krishnan; Mithun Bhowmick

doi:10.2174/1573396319666221128094843

Children And Adolescents With Irritable Bowel Syndrome: Treatment And Management

Curr Pediatr Rev. 2022 Nov 28. doi: 10.2174/1573396319666221128094843. Online ahead of print.

Authors

Ankita Wal¹, Pranay Wal¹, Neha Verma¹, Shiv Shanker Pandey², Karthickeyan Krishnan³, Mithun Bhowmick⁴

Affiliations

¹ Pranveer Singh Institute Of Technology Nh2 kanpur Agra Highway Bhaunti Kanpur UP,India.
² Tahira Institute of Medical Sciences Gida, Gorakhpur, UP , India.
³ Vels Institute of Science technology & Advanced studies Pallavaram , Chennai,600117,Tamil Nadu 600117.
⁴ D101 Shikshak Niketan,campus of Bengal college of Pharmaceutical Sciences and research , Bidhananagar Durgapur,West bengal 713212.

PMID: 36443973
DOI: 10.2174/1573396319666221128094843

Abstract

Background: Irritable bowel syndrome (IBS) is a disorder that causes stomach pain in children and adolescents. It may also impact one's quality of life. IBS is linked to gastrointestinal issues such as diarrhoea and constipation. Despite the identification of several potential pathophysiological pathways, the aetiology of IBS remained unknown.

Objective: The aim of this paper is to discuss the diagnosis, pathogenesis, case studies and treatment of Irritable bowel syndrome in children and adolescents.

Method: This systematic review covered relevant papers from the previous ten years that were accessible in Science Direct, Elsevier, NCBI, and Web of Science related to the pathophysiology and function of pharmacological drugs such as antidepressants, antispasmodics, prokinetics, and antibiotics in children with irritable bowel syndrome.

Result: Only a few prospective therapy techniques have been investigated in children, and even fewer of those have been demonstrated to be effective. This article presents case studies including 50-59 children, which demonstrate a favourable acceptable impact that is more effective than a placebo in terms of reducing symptoms and improving the overall quality of life in children who have irritable bowel syndrome. Furthermore, the majority of the pathophysiological explanations and treatment options discussed are based on adult studies. These major issues arose when treating paediatric IBS, and they must be addressed in order to properly treat children with IBS. Trials that focus on many combinations of pharmacological and non-pharmacological therapies seem to be more helpful.

Discussion: In recent years, a number of systematic reviews have been conducted to evaluate the efficacy of medication treatments in children for IBS; however, the dependability of these systematic reviews needs to be further investigated owing to the various experimental designs and levels of evidence used. This article highlights paediatric therapy options, including pharmaceutical medications such as antidepressants, antispasmodics, prokinetics, and antibiotics. The goal is to alleviate IBS symptoms while also enhancing the quality of life for children with this illness.

Keywords: Anti-depressant; Irritable bowel syndrome; Microbiota; abdominal pain.; diarrhoea.