Non-canonical Wnt signaling in the eye

Ruchi Shah; Cynthia Amador; Steven T Chun; Sean Ghiam; Mehrnoosh Saghizadeh; Andrei A Kramerov; Alexander V Ljubimov

doi:10.1016/j.preteyeres.2022.101149

Non-canonical Wnt signaling in the eye

Prog Retin Eye Res. 2023 Jul:95:101149. doi: 10.1016/j.preteyeres.2022.101149. Epub 2022 Nov 25.

Authors

Ruchi Shah¹, Cynthia Amador¹, Steven T Chun², Sean Ghiam³, Mehrnoosh Saghizadeh⁴, Andrei A Kramerov¹, Alexander V Ljubimov⁵

Affiliations

¹ Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Regenerative Medicine Institute Eye Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
² Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Regenerative Medicine Institute Eye Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA; University of California Los Angeles, Los Angeles, CA, USA.
³ Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Regenerative Medicine Institute Eye Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Sackler School of Medicine, New York State/American Program of Tel Aviv University, Tel Aviv, Israel.
⁴ Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Regenerative Medicine Institute Eye Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
⁵ Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Regenerative Medicine Institute Eye Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: ljubimov@cshs.org.

PMID: 36443219
PMCID: PMC10209355 (available on 2024-07-01)
DOI: 10.1016/j.preteyeres.2022.101149

Abstract

Wnt signaling comprises a group of complex signal transduction pathways that play critical roles in cell proliferation, differentiation, and apoptosis during development, as well as in stem cell maintenance and adult tissue homeostasis. Wnt pathways are classified into two major groups, canonical (β-catenin-dependent) or non-canonical (β-catenin-independent). Most previous studies in the eye have focused on canonical Wnt signaling, and the role of non-canonical signaling remains poorly understood. Additionally, the crosstalk between canonical and non-canonical Wnt signaling in the eye has hardly been explored. In this review, we present an overview of available data on ocular non-canonical Wnt signaling, including developmental and functional aspects in different eye compartments. We also discuss important changes of this signaling in various ocular conditions, such as keratoconus, aniridia-related keratopathy, diabetes, age-related macular degeneration, optic nerve damage, pathological angiogenesis, and abnormalities in the trabecular meshwork and conjunctival cells, and limbal stem cell deficiency.

Keywords: Calcium signaling; Conjunctiva; Cornea; Eye development; Eye diseases; Lens; Planar cell polarity; Retina; Stem cells; Wnt signaling.

Publication types

Review

MeSH terms

Cell Differentiation
Conjunctiva / metabolism
Humans
Trabecular Meshwork
Wnt Signaling Pathway* / physiology
beta Catenin* / metabolism

Substances

beta Catenin

Abstract

Publication types

MeSH terms

Substances

Grants and funding