Epithelial lining fluid concentrations of ceftriaxone in children with community-acquired pneumonia

Yi-Ning Dong; Ya-Kun Wang; Qian Li; Bo-Hao Tang; John van den Anker; Guo-Xiang Hao; Yi Zheng; Li-Yuan Tian; Dian-Ping You; Yue-E Wu; Wei Zhao

doi:10.1111/bcp.15616

Epithelial lining fluid concentrations of ceftriaxone in children with community-acquired pneumonia

Br J Clin Pharmacol. 2023 Apr;89(4):1491-1494. doi: 10.1111/bcp.15616. Epub 2022 Dec 14.

Authors

Yi-Ning Dong^{1

2}, Ya-Kun Wang³, Qian Li⁴, Bo-Hao Tang¹, John van den Anker^{5

6

7}, Guo-Xiang Hao¹, Yi Zheng¹, Li-Yuan Tian³, Dian-Ping You⁸, Yue-E Wu¹, Wei Zhao^{1

9}

Affiliations

¹ Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
² Department of Pharmacy, Shandong Provincial Third Hospital, Shandong University, Jinan, China.
³ Department of Respiratory Care, Children's Hospital of Hebei Province affiliated to Hebei Medical University, Shijiazhuang, China.
⁴ Department of Clinical Pharmacy, Clinical Trial Center, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, China.
⁵ Division of Clinical Pharmacology, Children's National Hospital, Washington, District of Columbia, USA.
⁶ Departments of Pediatrics, Pharmacology & Physiology, Genomics and Precision Medicine, School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia, USA.
⁷ Department of Paediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel, University of Basel, Switzerland.
⁸ Pediatric Research Institute, Children's Hospital of Hebei Province affiliated to Hebei Medical University, Shijiazhuang, China.
⁹ NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, Qilu Hospital of Shandong University, Shandong University, Jinan, China.

PMID: 36440759
DOI: 10.1111/bcp.15616

Abstract

Ceftriaxone is widely used in children with community-acquired pneumonia. Currently, there are no available data regarding epithelial lining fluid (ELF) concentrations of ceftriaxone in children. Thus, blood and bronchoalveolar lavage fluids samples were collected by using an opportunistic sampling design, then we determined plasma and ELF concentrations in 22 children (0.5-11.7 years), with a total of 36 plasma and 22 ELF samples available for analysis. Ceftriaxone plasma and ELF concentrations ranged from 1.07 to 138.71 mg/L and from 0.61 to 26.69 mg/L, respectively. Ceftriaxone concentration in ELF was 12.18 ± 5.15 (mean ± standard deviation) times higher than that in plasma, ranging from 1.29 to 20.44.

Keywords: ELF concentrations; ceftriaxone; children; community-acquired pneumonia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents
Bronchoalveolar Lavage Fluid
Ceftriaxone*
Child
Humans
Pneumonia* / drug therapy

Substances

Ceftriaxone
Anti-Bacterial Agents