A genetic association study reveals the relationship between the oral microbiome and anxiety and depression symptoms

Chun'e Li; Yujing Chen; Yan Wen; Yumeng Jia; Shiqiang Cheng; Li Liu; Huijie Zhang; Chuyu Pan; Jingxi Zhang; Zhen Zhang; Xuena Yang; Peilin Meng; Yao Yao; Feng Zhang

doi:10.3389/fpsyt.2022.960756

A genetic association study reveals the relationship between the oral microbiome and anxiety and depression symptoms

Front Psychiatry. 2022 Nov 10:13:960756. doi: 10.3389/fpsyt.2022.960756. eCollection 2022.

Authors

Chun'e Li¹, Yujing Chen¹, Yan Wen¹, Yumeng Jia¹, Shiqiang Cheng¹, Li Liu¹, Huijie Zhang¹, Chuyu Pan¹, Jingxi Zhang¹, Zhen Zhang¹, Xuena Yang¹, Peilin Meng¹, Yao Yao¹, Feng Zhang¹

Affiliation

¹ Key Laboratory of Trace Elements and Endemic Diseases, School of Public Health, Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, Health Science Center, Xi'an Jiaotong University, Xi'an, China.

Abstract

Background: Growing evidence supports that alterations in the gut microbiota play an essential role in the etiology of anxiety, depression, and other psychiatric disorders. However, the potential effect of oral microbiota on mental health has received little attention.

Methods: Using the latest genome-wide association study (GWAS) summary data of the oral microbiome, polygenic risk scores (PRSs) of 285 salivary microbiomes and 309 tongue dorsum microbiomes were conducted. Logistic and linear regression models were applied to evaluate the relationship between salivary-tongue dorsum microbiome interactions with anxiety and depression. Two-sample Mendelian randomization (MR) was utilized to compute the causal effects between the oral microbiome, anxiety, and depression.

Results: We observed significant salivary-tongue dorsum microbiome interactions related to anxiety and depression traits. Significantly, one common interaction was observed to be associated with both anxiety score and depression score, Centipeda periodontii SGB 224 × Granulicatella uSGB 3289 (P _{depressionscore} = 1.41 × 10^-8, P _anxietyscore = 5.10 × 10^-8). Furthermore, we detected causal effects between the oral microbiome and anxiety and depression. Importantly, we identified one salivary microbiome associated with both anxiety and depression in both the UKB database and the Finngen public database, Eggerthia (P _{IVW - majordepression - UKB} = 2.99 × 10^-6, P _{IVW - Self - reportedanxiety/panicattacks - UKB} = 3.06 × 10^-59, P _{IVW - depression - Finngen} = 3.16 × 10 $_{,}^{- 16}$ P _{IVW - anxiety - Finngen} = 1.14 × 10^-115).

Conclusion: This study systematically explored the relationship between the oral microbiome and anxiety and depression, which could help improve our understanding of disease pathogenesis and propose new diagnostic targets and early intervention strategies.

Keywords: Mendelian Randomization (MR); anxiety; depression; oral microbiome; polygenic risk scores (PRS).