A Computational Model of Blood D-Dimer, Cystatin C, and CRP Levels Predicts the Risk of Intracranial Aneurysms and their Rupture

Comput Intell Neurosci. 2022 Nov 18:2022:2216509. doi: 10.1155/2022/2216509. eCollection 2022.

Abstract

Objective: The aim of this study is to construct a computational model of blood D-dimer, cystatin C, and CRP levels and to predict the risk of intracranial aneurysms and their rupture.

Methods: A total of 69 intracranial aneurysms patients were selected as the case group, including 28 cases in the ruptured group and 41 cases in the unruptured group. Another 64 non-intracranial aneurysm patients were selected as the control group. The detection results of serum D-dimer, cystatin C, and CRP were collected. The logistic regression computational model was used to analyze the occurrence and risk factors of intracranial aneurysms. The receiver operating curves (ROC) of serum D-dimer, cystatin C, and C reactive protein (CRP) levels for predicting intracranial aneurysms and their rupture were drawn, and the area under the curve (AUC), sensitivity, and specificity were calculated.

Results: The serum levels of D-dimer, cystatin C, and CRP in patients with intracranial aneurysms were significantly higher than those in the control group and the differences were statistically significant (P < 0.05). The serum levels of D-dimer, cystatin C, and CRP in patients with ruptured intracranial aneurysms were higher than those in patients with unruptured intracranial aneurysms, and the differences were also statistically significant (P < 0.05). The combined detection of serum D-dimer, cystatin C, and CRP levels has a higher AUC (0.9014) for predicting intracranial aneurysms and higher AUC (0.9412) for predicting ruptured intracranial aneurysms than D-dimer (0.7118 and 0.8750, respectively), cystatin C (0.6489 and 0.6180, respectively), and CRP (0.7764 and 0.6551, respectively) independent detection; the combined detection had a sensitivity of 93.75% and 87.80 for predicting the occurrence and rupture of intracranial aneurysms, and the specificity was 68.12% and 92.86%, respectively.

Conclusion: The combined detection of serum D-dimer, cystatin C, and CRP levels is a very valuable indicator for predicting the occurrence and rupture of intracranial aneurysms, and combined detection can provide scientific evidence-based guidance for clinical prediction of the occurrence and rupture of intracranial aneurysms.

Publication types

  • Retracted Publication

MeSH terms

  • Aneurysm, Ruptured* / blood
  • Aneurysm, Ruptured* / diagnosis
  • Aneurysm, Ruptured* / etiology
  • C-Reactive Protein* / analysis
  • Computer Simulation
  • Cystatin C* / blood
  • Fibrin Fibrinogen Degradation Products* / analysis
  • Humans
  • Intracranial Aneurysm* / blood
  • Intracranial Aneurysm* / complications
  • Intracranial Aneurysm* / diagnosis
  • Models, Cardiovascular
  • Predictive Value of Tests
  • Risk Factors

Substances

  • Cystatin C
  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D
  • C-Reactive Protein