The role of TIGAR in nervous system diseases

Bei Huang; Xiaoling Lang; Xihong Li

doi:10.3389/fnagi.2022.1023161

The role of TIGAR in nervous system diseases

Front Aging Neurosci. 2022 Nov 9:14:1023161. doi: 10.3389/fnagi.2022.1023161. eCollection 2022.

Authors

Bei Huang^{1

2}, Xiaoling Lang^{1

2}, Xihong Li^{1

2}

Affiliations

¹ West China Second University Hospital, Sichuan University, Chengdu, China.
² Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.

Abstract

TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions include anti-oxidative stress, reducing inflammation, maintaining mitochondrial function, inhibiting apoptosis, reducing autophagy etc. This paper reviews the research of TIGAR in neurological diseases, including stroke, Parkinson's disease (PD), Alzheimer's disease (AD), seizures and brain tumors, aiming to provide reference for the development of new therapeutic targets.

Keywords: AD; PD; TIGAR; brain tumors; nervous system diseases; seizures; stroke.

Publication types

Review