Alternations of vitamin D and cognitive function in first-diagnosed and drug-naïve BD patients: Physical activity as a moderator

Sujuan Li; Xuelei Xu; Yan Qiu; Ziwei Teng; Jieyu Liu; Hui Yuan; Jindong Chen; Yuxi Tan; Min Yang; Kun Jin; Baoyan Xu; Hui Tang; Ziru Zhao; Bolun Wang; Hui Xiang; Haishan Wu

doi:10.1016/j.jad.2022.11.064

Alternations of vitamin D and cognitive function in first-diagnosed and drug-naïve BD patients: Physical activity as a moderator

J Affect Disord. 2023 Feb 15:323:153-161. doi: 10.1016/j.jad.2022.11.064. Epub 2022 Nov 25.

Authors

Sujuan Li¹, Xuelei Xu¹, Yan Qiu¹, Ziwei Teng¹, Jieyu Liu², Hui Yuan³, Jindong Chen¹, Yuxi Tan¹, Min Yang¹, Kun Jin¹, Baoyan Xu⁴, Hui Tang¹, Ziru Zhao¹, Bolun Wang⁵, Hui Xiang⁶, Haishan Wu⁷

Affiliations

¹ Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China; National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
² Department of Ultrasound Diagnostic, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
³ Department of Stomatology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
⁴ Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China; Hebei Provincial Mental Health Center, No.572 Dongfeng East RD., Baoding City 071000, Hebei Province, China; National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
⁵ Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
⁶ Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China; National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China. Electronic address: 452095746@csu.edu.cn.
⁷ Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China; National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China. Electronic address: wuhaishan@csu.edu.cn.

PMID: 36436763
DOI: 10.1016/j.jad.2022.11.064

Abstract

Background: The pathophysiological mechanism of cognitive impairments of bipolar disorder (BD) has not yet been completely revealed. It is well known that Vitamin D and physical activity (PA) are associated with BD. However, specific links between Vitamin D and cognitive deficits in BD are still unclear.

Method: The serum levels of vitamin D were measured. The cognitive performances of 102 first-diagnosed and drug-naïve BD patients were evaluated for analysis. The repeatable battery for the assessment of neuropsychological status (RBANS) and the Stroop Color-Word test was used in this study. PA was collected by international physical activity questionnaire.

Result: Patients with BD had high levels of serum vitamin D. Furthermore, immediate and delayed memory was negatively associated with vitamin D levels in patients' group. The serum levels of vitamin D in patients with low PA were positively associated with memory. However, increased PA attenuated the protective effect of vitamin D on executive cognition.

Conclusion: It is concluded that the increased levels of vitamin D were observed in the serum of patients with BD. Thus, it is found that more PA is less beneficial to cognition of patients with BD than longer resting.

Keywords: Bipolar disorder; Cognitive function; Executive function; Physical activity; Vitamin D.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bipolar Disorder* / psychology
Cognition
Exercise
Humans
Neuropsychological Tests
Vitamin D
Vitamins

Substances

Vitamin D
Vitamins