Preeclampsia in women with lupus - Influence of aspirin and hydroxychloroquine on pregnancy outcome

Jessica Phillips; Elizabeth Nathan; Dorothy Graham

doi:10.1016/j.preghy.2022.11.006

Preeclampsia in women with lupus - Influence of aspirin and hydroxychloroquine on pregnancy outcome

Pregnancy Hypertens. 2023 Mar:31:14-16. doi: 10.1016/j.preghy.2022.11.006. Epub 2022 Nov 19.

Authors

Jessica Phillips¹, Elizabeth Nathan², Dorothy Graham³

Affiliations

¹ Department of Obstetrics and Gynaecology, King Edward Memorial Hospital, Perth, Australia. Electronic address: jessica.phillips@health.wa.gov.au.
² Division of Obstetrics and Gynaecology, University of Western Australia, Perth, Australia.
³ Department of Obstetrics and Gynaecology, King Edward Memorial Hospital, Perth, Australia; University of Western Australia, Perth, Australia.

PMID: 36436478
DOI: 10.1016/j.preghy.2022.11.006

Abstract

Systemic lupus erythematosus is associated with increased rates of preeclampsia. Both aspirin and hydroxychloroquine are recommended for preeclampsia prophylaxis in women with lupus but there are no studies examining related outcomes in an Australian cohort. This was a single centre retrospective study of lupus affected pregnancies. The association between hydroxychloroquine, aspirin and preeclampsia was examined using adjusted logistic regression models. In 95 pregnancies, hydroxychloroquine was associated with a significantly lower risk of preeclampsia (adjusted OR 0.16, 95 % CI 0.04-0.64) but there was no association between aspirin and preeclampsia (adjusted OR 1.34, 95 % CI 0.33-5.40).

Keywords: Aspirin; Hydroxychloroquine; Preeclampsia; Systemic lupus erythematosus.

MeSH terms

Aspirin
Australia
Female
Humans
Hydroxychloroquine / therapeutic use
Pre-Eclampsia* / prevention & control
Pregnancy
Pregnancy Complications* / drug therapy
Pregnancy Outcome
Retrospective Studies

Substances

Hydroxychloroquine
Aspirin