Partial Efficacy of Vigabatrin in an Infant With West Syndrome Due to Pyruvate Dehydrogenase Complex Deficiency: A Case Report

Mitsuo Motobayashi; Shun Munakata; Noritaka Kitazawa; Takuya Fushimi; Kei Murayama; Yuji Inaba

doi:10.1016/j.pediatrneurol.2022.10.012

Partial Efficacy of Vigabatrin in an Infant With West Syndrome Due to Pyruvate Dehydrogenase Complex Deficiency: A Case Report

Pediatr Neurol. 2023 Jan:138:98-100. doi: 10.1016/j.pediatrneurol.2022.10.012. Epub 2022 Nov 2.

Authors

Mitsuo Motobayashi¹, Shun Munakata², Noritaka Kitazawa³, Takuya Fushimi⁴, Kei Murayama⁵, Yuji Inaba⁶

Affiliations

¹ Division of Neuropediatrics, Nagano Children's Hospital, Azumino, Japan; Life Science Research Center, Nagano Children's Hospital, Azumino, Japan; Neuro-Care Center, Nagano Children's Hospital, Azumino, Japan; Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan. Electronic address: s001072@shinshu-u.ac.jp.
² Life Science Research Center, Nagano Children's Hospital, Azumino, Japan.
³ Department of Ophthalmology, Nagano Children's Hospital, Azumino, Japan.
⁴ Center for Medical Genetics and Department of Metabolism, Chiba Children's Hospital, Chiba, Japan.
⁵ Center for Medical Genetics and Department of Metabolism, Chiba Children's Hospital, Chiba, Japan; Diagnostics and Therapeutic of Intractable Diseases, Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
⁶ Division of Neuropediatrics, Nagano Children's Hospital, Azumino, Japan; Life Science Research Center, Nagano Children's Hospital, Azumino, Japan; Neuro-Care Center, Nagano Children's Hospital, Azumino, Japan.

PMID: 36436329
DOI: 10.1016/j.pediatrneurol.2022.10.012

No abstract available

Keywords: Adrenocorticotropic hormone therapy; Infant; Ketogenic diet; Pyruvate dehydrogenase complex deficiency; Vigabatrin; West syndrome; Zonisamide.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adrenocorticotropic Hormone / therapeutic use
Anticonvulsants / adverse effects
Humans
Infant
Pyruvate Dehydrogenase Complex Deficiency Disease* / complications
Pyruvate Dehydrogenase Complex Deficiency Disease* / drug therapy
Spasms, Infantile* / drug therapy
Spasms, Infantile* / etiology
Vigabatrin / therapeutic use

Substances

Vigabatrin
Anticonvulsants
Adrenocorticotropic Hormone