Regulatory effects of autoantibody IgG on osteoclastogenesis

Tong Yu; Wenlin Qiu; Guo-Min Deng

doi:10.1016/j.clim.2022.109200

Regulatory effects of autoantibody IgG on osteoclastogenesis

Clin Immunol. 2023 Jan:246:109200. doi: 10.1016/j.clim.2022.109200. Epub 2022 Nov 23.

Authors

Tong Yu¹, Wenlin Qiu¹, Guo-Min Deng²

Affiliations

¹ Department of Rheumatology and Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Rheumatology and Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: gmdeng@hust.edu.cn.

PMID: 36435446
DOI: 10.1016/j.clim.2022.109200

Abstract

Inflammatory arthritis is common in both systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), and eventually leads to bone homeostasis disorders. However, RA patients generally have severe bone destruction, which is rare in SLE patients. Recent studies have demonstrated that anti-citrullinated protein antibodies are important factors leading to bone destruction in RA. On the other hand, SLE patients present deposition of autoantibodies in the joints, which plays an important role in bone protection. These different phenomena occur because of the effects of the autoantibodies on the monocytes/macrophages during osteoclastogenesis, and the mechanisms underlying these effects differ between SLE and RA patients.

Keywords: Autoantibody IgG; FcγR; Glycosylation; Osteoclastogenesis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Arthritis, Rheumatoid*
Autoantibodies
Humans
Immunoglobulin G
Lupus Erythematosus, Systemic*
Osteogenesis

Substances

Autoantibodies
Immunoglobulin G