Exosome-based approaches in the management of Alzheimer's disease

Raghuram Kandimalla; Mohd Saeed; Neetu Tyagi; Ramesh C Gupta; Farrukh Aqil

doi:10.1016/j.neubiorev.2022.104974

Exosome-based approaches in the management of Alzheimer's disease

Neurosci Biobehav Rev. 2023 Jan:144:104974. doi: 10.1016/j.neubiorev.2022.104974. Epub 2022 Nov 23.

Authors

Raghuram Kandimalla¹, Mohd Saeed², Neetu Tyagi³, Ramesh C Gupta⁴, Farrukh Aqil⁵

Affiliations

¹ Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
² Department of Biology, College of Sciences, University of Hail, PO Box 2240, Hail, Saudi Arabia.
³ Department of Physiology, University of Louisville, Louisville, KY 40202, USA.
⁴ Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.
⁵ Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA; Department of Medicine, University of Louisville, Louisville, KY 40202, USA. Electronic address: farrukh.aqil@louisville.edu.

PMID: 36435392
DOI: 10.1016/j.neubiorev.2022.104974

Abstract

Alzheimer's disease (AD) has been the most extensively studied neurological disorders that affects millions of individuals globally and is associated with misfolding of proteins in the brain. Amyloid-β and tau are predominantly involved in the pathogenesis of AD. Therapeutic interventions and nanotechnological advancements are useful only in managing the AD symptoms and the cure for this disease remains elusive. Exosomes, originating from most cell and tissue types are regarded as a double-edged sword, considering their roles in the progression and treatment of AD. Exosomes can be manipulated as drug delivery vehicles for a wide range of therapeutic cargos-both small molecules and macromolecules. Herein, we review the roles of exosomes in the pathology, diagnosis, and treatment of AD and highlight their application as a drug carrier to the brain for AD treatment.

Keywords: Alzheimer's disease; Blood brain barrier; Drug delivery; Exosome; Gene therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease* / metabolism
Amyloid beta-Peptides / metabolism
Brain / metabolism
Exosomes* / metabolism
Exosomes* / pathology
Humans
tau Proteins / metabolism

Substances

Amyloid beta-Peptides
tau Proteins