Novel insights into the N6-methyladenosine RNA modification and phytochemical intervention in lipid metabolism

Linghuan Li; Yuanhai Sun; Weiwei Zha; Lingqing Li; Hanbing Li

doi:10.1016/j.taap.2022.116323

Novel insights into the N⁶-methyladenosine RNA modification and phytochemical intervention in lipid metabolism

Toxicol Appl Pharmacol. 2022 Dec 15:457:116323. doi: 10.1016/j.taap.2022.116323. Epub 2022 Nov 24.

Authors

Linghuan Li¹, Yuanhai Sun¹, Weiwei Zha¹, Lingqing Li², Hanbing Li³

Affiliations

¹ Institute of Pharmacology, Zhejiang University of Technology, Hangzhou 310014, PR China.
² Taizhou Municipal Hospital, Taizhou University, Taizhou 318000, PR China.
³ Institute of Pharmacology, Zhejiang University of Technology, Hangzhou 310014, PR China. Electronic address: hanniballee@zjut.edu.cn.

PMID: 36427654
DOI: 10.1016/j.taap.2022.116323

Abstract

Epitranscriptome (RNA modification) plays a vital role in a variety of biological events. N⁶-methyladenosine (m⁶A) modification is the most prevalent mRNA modification in eukaryotic cells. Dynamic and reversible m⁶A modification affects the plasticity of epitranscriptome, which plays an essential role in lipid metabolism. In this review, we comprehensively delineated the role and mechanism of m⁶A modification in the regulation of lipid metabolism in adipose tissue and liver, and summarized phytochemicals that improve lipid metabolism disturbance by targeting m⁶A regulator, providing potential lead candidates for drug therapeutics. Moreover, we discussed the main challenges and possible future directions in this field.

Keywords: Lipid metabolism; MAFLD; N(6)-methyladenosine; Obesity.

Publication types

Review