Mouse study of combined DNA/protein COVID-19 vaccine to boost high levels of antibody and cell mediated immune responses

Emerg Microbes Infect. 2023 Dec;12(1):2152388. doi: 10.1080/22221751.2022.2152388.

Authors

Qian He¹, Shuying Liu², Zhenglun Liang¹, Shan Lu³, Wei Cun⁴, Qunyan Mao¹

Affiliations

¹ National Institute for Food and Drug Control, Beijing, People's Republic of China.
² SYL-Consulting, Thousand Oaks, CA, USA.
³ Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
⁴ Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, People's Republic of China.

No abstract available

Keywords: DNA vaccine; SARS-CoV-2; T cells; antibody; heterologous prime – boost; protein vaccine.

MeSH terms

Animals
Antibodies, Neutralizing
Antibodies, Viral
COVID-19 Vaccines*
COVID-19* / prevention & control
DNA
Humans
Immunity, Cellular
Mice
Vaccination

Substances

COVID-19 Vaccines
Antibodies, Neutralizing
DNA
Antibodies, Viral

Grants and funding

This work was supported by Emergency Key Program of Guangzhou Laboratory (grant 467 No. EKPG21-30-1).