Predictors for Treatment Outcomes in Patients with Multi-drug Resistant Tuberculosis - China, 2018-2020

Shunxian Zhang; Lei Qiu; Dingzhong Wu; Shaoyan Zhang; Chenhui Pan; Cui Li; Heping Xiao; Fuli Huang; Hua Wang; Feng Jiang; Huiyong Zhang; Peiyong Zheng; Zhenhui Lu

doi:10.46234/ccdcw2022.187

Predictors for Treatment Outcomes in Patients with Multi-drug Resistant Tuberculosis - China, 2018-2020

China CDC Wkly. 2022 Oct 14;4(41):907-911. doi: 10.46234/ccdcw2022.187.

Authors

Shunxian Zhang¹, Lei Qiu¹, Dingzhong Wu¹, Shaoyan Zhang¹, Chenhui Pan¹, Cui Li¹, Heping Xiao², Fuli Huang³, Hua Wang⁴, Feng Jiang⁵, Huiyong Zhang¹, Peiyong Zheng¹, Zhenhui Lu¹

Affiliations

¹ Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² The Lung Hospital Affiliated to Tongji University, Shanghai, China.
³ Chongqing Infections Disease of Medical Center, Nanjing City, Jiangsu Province, China.
⁴ Anhui Chest Hospital, Hefei City, Anhui Province, China.
⁵ Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing, China.

Abstract

What is already known about this topic?: Multi-drug resistant tuberculosis (MDR-TB) is a critical global public health problem.

What is added by this report?: Sputum cultures and lung images show a strong association with treatment outcomes, serving as a multi-dimensional approach to identify MDR-TB patients with poor outcomes.

What are the implications for public health practice?: The results imply that funds and policy investments should be increased by early monitoring of MDR-TB patients, especially regarding imaging and sputum bacterium. By informing physicians on changes to the therapeutic schedule, treatment outcomes can be improved.

Keywords: Multi-drug Resistant; Treatment Outcomes; Tuberculosis.

Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2022.

Grants and funding

Supported by the fund of Medical Innovation Research Special Project of the Shanghai “Science and Technology Innovation Action Plan” (No.21Y11922500), the Three-year Action Plan for Promoting Clinical Skills and Innovation Ability of Municipal Hospitals (SHDC2022CRS039), the fund of talent fund of Longhua Hospital (LH001.007) and the 13th Five-Year National Science and Technology Major Project for Infectious Diseases (2018ZX10725-509)