The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium

Tatiana Boronikhina; Gennadii Piavchenko; Artem Venediktov; Ekaterina Kustavinova; Svetlana Mukhamedova; Natalia Kartashkina; Sergey Kuznetsov; Igor Meglinski; Alexander Yatskovskiy

doi:10.1016/j.heliyon.2022.e11658

The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium

Heliyon. 2022 Nov 17;8(11):e11658. doi: 10.1016/j.heliyon.2022.e11658. eCollection 2022 Nov.

Authors

Tatiana Boronikhina¹, Gennadii Piavchenko¹, Artem Venediktov¹, Ekaterina Kustavinova¹, Svetlana Mukhamedova¹, Natalia Kartashkina¹, Sergey Kuznetsov¹, Igor Meglinski^{2

3}, Alexander Yatskovskiy¹

Affiliations

¹ Department of Histology, Cytology, and Embryology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
² Opto-Electronics and Measurement Techniques, Faculty of Information and Electrical Engineering, University of Oulu, Oulu, Finland.
³ College of Engineering and Physical Sciences, Aston University, Birmingham, UK.

Abstract

Background: Our study has immunohistochemically examined T cells localization and number as well as proliferative activity level for the bulbourethral gland epithelium in men of different ages, using monoclonal antibodies against CD45RO and proliferating cell nuclear antigen (PCNA).

Results: We have found that the T cells have been localized mainly in excretory ducts epithelium of the glands in any age group, meanwhile their relative number varies with age. The excretory ducts epithelium has shown a high proliferative activity when in acini the PCNA index has been low. Postnatal dynamics of the epithelium proliferative activity positively correlates with age-related density fluctuations in lymphocytic infiltration of the glands.

Conclusions: We consider that intraepithelial T cells may contribute to the regulation of epithelial cells proliferation in the bulbourethral glands.

Keywords: Epithelial proliferation; Human bulbourethral glands; Lymphocytic infiltration; Proliferating cell nuclear antigen; T cells.