Comparative Study on the Measurement of Liver LICdw between Ferriscan and T2* Based LICdw Obtained by Different Software's

Fengming Xu; Jixing Yi; Bumin Liang; Cheng Tang; Qing Feng; Peng Peng

doi:10.4084/MJHID.2022.072

Comparative Study on the Measurement of Liver LICdw between Ferriscan and T2* Based LICdw Obtained by Different Software's

Mediterr J Hematol Infect Dis. 2022 Nov 1;14(1):e2022072. doi: 10.4084/MJHID.2022.072. eCollection 2022.

Authors

Fengming Xu^#^{1

2}, Jixing Yi^#³, Bumin Liang⁴, Cheng Tang^{1

2}, Qing Feng³, Peng Peng^{1

2}

Affiliations

¹ Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
² NHC Key Laboratory of Thalassemia Medicine (Guangxi Medical University), Guangxi Zhuang Autonomous, Region Peoples Republic of China.
³ Department of Radiology, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou Workers' Hospital, Liuzhou, 545005, Guangxi Zhuang Autonomous Region, China.
⁴ School of International Education, Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.

^# Contributed equally.

Abstract

Objective: To explore the relationship between the liver iron concentration (LIC_F) from FerriScan and T2* based LIC obtained by Circle Cardiovascular Imaging CVI42 (CVI42), CMRtools/Thalassemia Tools (CMRtools), and Excel spreadsheet (Excel).

Methods: Liver T2* values in 78 thalassemia patients were measured using CVI42, CMRtools, and Excel. Then the Garbowski formula was used to obtain LIC from T2*. Finally, the relationship of the LIC measured by the above three software and the LIC_F were compared.

Results: There was no statistical difference between the T2* values measured by CVI42, CMRtools, and Excel (P>0.05), but there was a high degree of consistency between them (P<0.001), and there was a high linear positive correlation between them (P<0.001). There was no statistical difference between the LIC clinical grading results of CVI42, CMRtools, and Excel and LIC_F grading results (P>0.05), and they were highly consistent (P<0.001).

Conclusion: The liver T2* values measured by CVI42, CMRtools, and Excel are equivalent. The LIC measured by CVI42, CMRtools, and Excel is equivalent to the LIC_F.

Keywords: Comparative study; Iron overload; Liver iron concentration; Thalassemia.