Retrospective Analysis of Complications After Gonadal Vein Interventions for Pelvic Venous Disorder

Sergey G Gavrilov; Nadezhda Yu Mishakina; Alexey V Vasilyiev; Konstantin V Kirsanov

doi:10.1016/j.jss.2022.10.062

Retrospective Analysis of Complications After Gonadal Vein Interventions for Pelvic Venous Disorder

J Surg Res. 2023 Mar:283:249-258. doi: 10.1016/j.jss.2022.10.062. Epub 2022 Nov 21.

Authors

Sergey G Gavrilov¹, Nadezhda Yu Mishakina², Alexey V Vasilyiev², Konstantin V Kirsanov²

Affiliations

¹ Savelyev University Surgical Clinic, Pirogov Russian National Research Medical University, Moscow, Russia. Electronic address: gavriloffsg@mail.ru.
² Savelyev University Surgical Clinic, Pirogov Russian National Research Medical University, Moscow, Russia.

PMID: 36423473
DOI: 10.1016/j.jss.2022.10.062

Abstract

Introduction: To investigate and compare complications after gonadal vein embolization (GVE) with coils and gonadal vein resection (GVR) in patients with pelvic venous disorder (PeVD).

Methods: This single-center retrospective cohort study included 277 female patients with PeVD who underwent GVE with coils (n = 150) or GVR (n = 122) in the period from 2000 to 2020. The participants were selected from a cohort of 4975 patients with chronic pelvic pain (CPP), of whom 1107 suffered from the PeVD-related CPP and 305 underwent surgical or endovascular intervention on the gonadal veins. The GVR technique was open retroperitoneal in 92, endoscopic transperitoneal in 18, and retroperitoneal in 12 patients. Clinical outcomes included 30-day complication rates and 3-year PeVD recurrence rates. The pain intensity was assessed before and after the procedure using a visual analogue scale. All patients underwent duplex ultrasound after the procedure, and those with persisting pain and suspected gonadal vein perforation with coil were also examined using computed tomographic venography.

Results: A substantial pelvic pain relief was achieved within 30 d after GVE and GVR in 73% and 100% patients, accordingly (Р = 0.001). Complications after GVE were identified in 85 (56%) patients. The major complications included pelvic vein thrombosis (PVT) and calf deep vein thrombosis (24%), postembolization syndrome (22%), and coil protrusion (5.3%). Complications after GVR occurred in 14 (11%) patients and consisted of PVT (10%) and ileus (1.6%). The 3-year recurrence rates after GVE and GVR were 11% and 5%, accordingly (P = 0.04).

Conclusions: In patients with PeVD, the gonadal vein embolization with coils is associated with a high complication rate, which can be reduced with further development of the GVE technique, the use of new embolic agents, and the selection of a treatment method based on the patient's body composition.

Keywords: Complications; Gonadal vein embolization with coils; Gonadal vein resection; Pelvic venous disorder.

MeSH terms

Embolization, Therapeutic* / adverse effects
Female
Humans
Pelvic Pain / complications
Pelvic Pain / therapy
Pelvis / blood supply
Retrospective Studies
Treatment Outcome
Varicose Veins*
Veins