Total Synthesis of Terpenes and Their Biological Significance: A Critical Review

Aqsa Kanwal; Muhammad Bilal; Nasir Rasool; Muhammad Zubair; Syed Adnan Ali Shah; Zainul Amiruddin Zakaria

doi:10.3390/ph15111392

Total Synthesis of Terpenes and Their Biological Significance: A Critical Review

Pharmaceuticals (Basel). 2022 Nov 11;15(11):1392. doi: 10.3390/ph15111392.

Authors

Aqsa Kanwal¹, Muhammad Bilal², Nasir Rasool¹, Muhammad Zubair¹, Syed Adnan Ali Shah^{3

4}, Zainul Amiruddin Zakaria⁵

Affiliations

¹ Department of Chemistry, Government College University, Faisalabad 38000, Pakistan.
² School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
³ Faculty of Pharmacy, Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor, Malaysia.
⁴ Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor, Malaysia.
⁵ Borneo Research on Algesia, Inflammation and Neurodegeneration (BRAIN) Group, Faculty of Medicine and Health Sciences, Sabah Universiti Malaysia, Jalan UMS, Kota Kinabalu 88400, Sabah, Malaysia.

Abstract

Terpenes are a group of natural products made up of molecules with the formula (C₅H₈)_n that are typically found in plants. They are widely employed in the medicinal, flavor, and fragrance industries. The total synthesis of terpenes as well as their origin and biological potential are discussed in this review.

Keywords: natural product; terpenes; total synthesis.

Publication types

Review

Grants and funding

This research received no external funding.