Nicotine-Free E-Cigarettes Might Promote Tobacco Smoking Reduction Better Than Nicotine Delivery Devices: Results of a Double-Blind Randomized Controlled Trial at 1 Year

Curr Oncol. 2022 Nov 11;29(11):8579-8590. doi: 10.3390/curroncol29110676.

Abstract

The purpose of the present study was to determine whether the use of e-cigarettes to aid in quitting contributed to the increase in the pulmonary health of chronic smokers. The efficacy of e-cigarettes to support a successful smoking cessation attempt was also investigated. A total of 210 smokers (78 women) were enrolled in a screening program for the early detection of lung cancer and distributed in three arms: nicotine e-cigarette plus support, nicotine-free e-cigarette plus support, and support. Results showed that participants in the nicotine e-cigarette arm had a significant and fast decrease in daily cigarettes, but that later they resume smoking more than the other two groups. Conversely, participants in the other two arms showed similar daily consumption at the two evaluation points. Among abstinent participants, only 12.5% reported cough, while 48% of current smokers had pulmonary symptoms. Our study suggests that, in the long run, the use of a nicotine-free liquid may favor reducing smoking and could be considered a good option in a clinical setting.

Keywords: cancer screening; decision-making; e-cigarette; personality; smoking.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Electronic Nicotine Delivery Systems*
  • Female
  • Humans
  • Nicotiana
  • Nicotine
  • Smoking Cessation* / methods
  • Smoking Reduction* / methods

Substances

  • Nicotine

Grants and funding

This study was supported by the Young Investigator Research Program 8/2014 granted by Fondazione Umberto Veronesi (FUV). This work was also partially supported by: Italian Ministry of Health with “Ricerca corrente” and 5xmille funds (P.M.).