The number of patients with diabetic foot ulcer (DFU) has increased progressively year by year. Refractory DFU has brought great burden to the country and individuals. How to accelerate the healing of DFU has become the main emphasis of research. However currently, the mechanism of its refractory healing is not fully elucidated, and the correlation between the various mechanisms are not high. Therefore, its clinical standardization, and precise clinical diagnosis and treatment still face several challenges. Based on the progress of clinical research and basic research at home and abroad, this paper reviewed the specific mechanisms that lead to refractory DFU, with the focus on chronic inflammation, bacteria biofilm formation, high oxidative stress, growth factor inhibition, impaired microcirculation, and accumulation of advanced glycation end products.
糖尿病足溃疡患病人数逐年递增，糖尿病足溃疡难愈合，给国家及个人带来巨大负担。如何加速糖尿病足溃疡愈合成为研究的重点，但目前其难愈合机制尚未被完全阐明，各机制之间关联性不高，因此其临床标准化和精准化诊疗仍面临若干挑战。该文结合国内外临床研究与基础研究进展，围绕慢性炎症、细菌生物膜形成、高氧化应激、生长因子抑制、微循环障碍、晚期糖基化终末产物积累等导致糖尿病足溃疡难愈合的具体机制进行综述。.