Synthesis, characterization and anticancer activities of Zn2+, Cu2+, Co2+ and Ni2+ complexes involving chiral amino alcohols

Q Umar; Y Huang; A Nazeer; H Yin; J C Zhang; M Luo; X G Meng

doi:10.1039/d2ra05576g

Synthesis, characterization and anticancer activities of Zn²⁺, Cu²⁺, Co²⁺ and Ni²⁺ complexes involving chiral amino alcohols

RSC Adv. 2022 Nov 9;12(49):32119-32128. doi: 10.1039/d2ra05576g. eCollection 2022 Nov 3.

Authors

Q Umar¹, Y Huang¹, A Nazeer¹, H Yin¹, J C Zhang¹, M Luo¹, X G Meng²

Affiliations

¹ Department of Chemistry and Chemical Engineering, Hefei University of Technology Hefei 23000 P.R. China luomei@pku.edu.cn mengxianggao@ccnu.edu.cn.
² College of Chemistry, Central China Normal University Wuhan 430079 P.R. China.

Abstract

Seven new metal coordination complexes, [NiC₁₅H₄₃N₅O₁₁] (I), [Co₃C₃₆H₉₈N₆O₆] (II), [CuC₁₄H₃₂N₂O₆] (III), [Cu₂C₃₂H₄₃Cl₂N₂O₁₃] (IV), [Zn₂C₂₄H₃₂Cl₃N₃O₃] (V), [Co₃C₄₈H₆₆Cl₆N₆O₆] (VI), and [Zn (C₁₈H₄₅N₃O₃] (VII), have been synthesized from some direct reactions of amino-alcoholic ligands with metal salts in anhydrous methanol or ethanol medium. All the crystals of these seven complexes are crystallized in the chiral space groups (P2₁2₁2₁ for (I), (IV), (VI) and (VII); P2₁ for (III) and (V); and C₂ for (II), respectively). Their characteristic peaks were analyzed and assigned by FTIR, NMR, and UV-Vis and elemental analysis techniques. The anticancer activities of amino alcohol complexes (I)-(VII) showed cytotoxic effects against the human tumour cell line A549; among them, complex (V) showed the best activity with an IC₅₀ value of 17.8. The higher biological activity should be related to its di-nuclear zinc(ii) unit in which one zinc is only four-coordinated by four small chloride anions.