Assessment of SARS-CoV-2 vaccination status in SARS-COV-2 infected patients admitted in Dr Ruth K.M. Pfau, Civil Hospital Karachi

Tazeen Rasheed; Faiza Sadaqat Ali; Bader Faiyaz Zuberi; Rabiah Sadaf

doi:10.12669/pjms.38.8.5733

Assessment of SARS-CoV-2 vaccination status in SARS-COV-2 infected patients admitted in Dr Ruth K.M. Pfau, Civil Hospital Karachi

Pak J Med Sci. 2022 Nov-Dec;38(8):2089-2094. doi: 10.12669/pjms.38.8.5733.

Authors

Tazeen Rasheed¹, Faiza Sadaqat Ali², Bader Faiyaz Zuberi³, Rabiah Sadaf⁴

Affiliations

¹ Tazeen Rasheed, FCPS. Associate Professor, Department of Medicine/Gastroenterology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
² Faiza Sadaqat Ali, FCPS. Senior Registrar, Department of Medicine/Gastroenterology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
³ Bader Faiyaz Zuberi, FCPS. Meritorious Professor, Department of Medicine/Gastroenterology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
⁴ Rabiah Sadaf, FCPS. Consultant Physician, Dr Ruth K.M. Pfau, Civil Hospital Karachi, Pakistan.

Abstract

Objectives: To determine the frequency of vaccination status in patients with SARS-CoV-2 infection.

Methods: This case-control study was conducted at Dr Ruth KM Pfau Civil Hospital Karachi, Pakistan between September 2021 to October 2021. All patients who had positive PCR on nasopharyngeal swab for SARS-CoV-2 infection were included. Information regarding vaccination status and brand of vaccination administered and duration between the last dose of vaccine and positive PCR was noted. The disease status of patients was classified on admission into severe and non-severe disease.

Results: Study included 143 patients, out of which 58 (40.6%) were males and 85 (59.4%) were females. Majority of our patients (78.3%) were unvaccinated. Frequency of Severe SARS-CoV-2 Infection in fully vaccinated patients was less than in unvaccinated patients. The odds of developing severe COVID infection in unvaccinated patients versus vaccinated was 8.55 times higher (OR = 6.23, 95% CI 2.58-28.35). Proportion of vaccinated females was less as compared to males. Significant differences were found in severity between hypertension (p<.001), diabetes (<.001) and age (p<.001).

Conclusion: The frequency of SARS-CoV-2 infection was greater in unvaccinated patients. The odds of developing severe COVID infection in unvaccinated patients versus vaccinated was 8.55 times higher.

Keywords: Mortality; Odds Ratio; SARS-CoV-2; SARS-CoV-2 Vaccine.