A flexible surface-enhanced Raman Spectroscopy chip integrated with microlens

Feng Yang; Ping Wen; Lianggui Tang; Rongxiu Wang; Yiyan Wang; Dongling Li; Yi Xu; Li Chen

doi:10.1016/j.saa.2022.122129

A flexible surface-enhanced Raman Spectroscopy chip integrated with microlens

Spectrochim Acta A Mol Biomol Spectrosc. 2023 Feb 15;287(Pt 2):122129. doi: 10.1016/j.saa.2022.122129. Epub 2022 Nov 17.

Authors

Feng Yang¹, Ping Wen², Lianggui Tang³, Rongxiu Wang³, Yiyan Wang⁴, Dongling Li⁵, Yi Xu⁵, Li Chen⁶

Affiliations

¹ School of Artificial Intelligence, Chongqing Technology and Business University, Chongqing 400067, China. Electronic address: yf-1221@ctbu.edu.cn.
² College of Optoelectronic Engineering, Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Chongqing University, Chongqing 400044, China; School of Intelligent Manufacturing, Sichuan University of Arts and Science, Dazhou 635000, China.
³ School of Artificial Intelligence, Chongqing Technology and Business University, Chongqing 400067, China.
⁴ School of Intelligent Manufacturing, Sichuan University of Arts and Science, Dazhou 635000, China.
⁵ College of Optoelectronic Engineering, Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Chongqing University, Chongqing 400044, China.
⁶ College of Optoelectronic Engineering, Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Chongqing University, Chongqing 400044, China. Electronic address: CL2009@cqu.edu.cn.

PMID: 36413826
DOI: 10.1016/j.saa.2022.122129

Abstract

A novel flexible Surface-enhanced Raman Spectroscopy (SERS) chip integrated with microlens was proposed and designed, which consisted of PDMS film, planoconvex microlens, and silver nanoparticles (AgNPs) monolayer, and was of high signal collection efficiency. The flexible PDMS film integrated with microlens was designed by optical simulation, and fabricated by optimized micromachining process. AgNPs monolayer were uniformly assembled on the other side of the PDMS film through a liquid-liquid interface self-assembly method to form SERS chip. The prepared chip revealed excellent SERS performance with a Raman enhancement factor of about 10⁷ and a signal variation of <11.5 %. The SERS chip was successfully utilized for in-situ detection of thiram residues on tomato skins, and its characteristic peaks could still be clearly distinguished when the concentration was down to 2.5 μM. It was shown that the proposed SERS chip was suitable for in-situ detection of a real sample on complex surface morphology and shown potential prospect in the fields of chemical and biomedical detections.

Keywords: Ag nanoparticles; Flexible SERS chip; Microlens; SERS.

MeSH terms

Computer Simulation
Metal Nanoparticles*
Silver
Spectrum Analysis, Raman*
Thiram

Substances

Silver
Thiram