Global Prevalence and Associated Clinical Markers of Thrombocytopenia in People Living with HIV: Evidence from Meta-Analysis

Faisal K Alkholifi; Sayed Aliul Hasan Abdi; Marwa Qadri

doi:10.3390/clinpract12060091

Global Prevalence and Associated Clinical Markers of Thrombocytopenia in People Living with HIV: Evidence from Meta-Analysis

Clin Pract. 2022 Oct 31;12(6):867-875. doi: 10.3390/clinpract12060091.

Authors

Faisal K Alkholifi¹, Sayed Aliul Hasan Abdi², Marwa Qadri³

Affiliations

¹ Department of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
² Faculty of Pharmacy, Al Baha University, Al Baha 1988, Saudi Arabia.
³ Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 54943, Saudi Arabia.

Abstract

Thrombocytopenia is one of the complications in human immunodeficiency virus (HIV) patients. To improve the health outcomes of patients living with HIV, it is important to understand the prevalence and pattern of associated key clinical markers globally. This meta-analysis, therefore, aimed to estimate the pooled prevalence of and associated clinical marker of thrombocytopenia globally. Methodology: The meta-analysis was conducted as per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All statistical analyses were conducted using Stata. Twelve full-text papers out of 454 were eligible for meta-analysis. Results: Among 6686 participants, overall pooled prevalence of thrombocytopenia was 10.90% (95% CI: 7.91, 13.88) I2 = 93.62%. In addition, thrombocytopenia was more prevalent by 25.11% (95% CI: 13.33, 36.88) in patients with CD + T < 200 cells/μL, and less prevalent in patients with CD + T < 200 cells/μL 10.10% (95% CI: 7.37, 12.83), respectively. Conclusions and recommendations: This meta-analysis established the prevalence of thrombocytopenia among patients living with HIV, and that it may be more prevalent in patients with CD + T < 200 cells/μL indicating the necessity of routine screening for various haematological markers and a careful treatment plan for HIV patients.

Keywords: CD < 200 cells/μL; HIV; thrombocytopenia.

Grants and funding

The study was approved by Deanship of scientific research (DSR), Prince Sattam bin Abdul-Aziz University, Al-Kharj, Saudi Arabia under research grant No. 2019/03/11309.