Cytotoxic 4-phenylcoumarins from the flowering buds of Mesua ferrea

Xiya Chen; Zhiying Liu; Bi Zhong; Mengjie Zhu; Han Yao; Xiaojie Chen; Yongchao Lu; Shuyun Wang; Yaping Guo

doi:10.1080/14786419.2022.2148378

Cytotoxic 4-phenylcoumarins from the flowering buds of Mesua ferrea

Nat Prod Res. 2023 Nov-Dec;37(22):3741-3750. doi: 10.1080/14786419.2022.2148378. Epub 2022 Nov 22.

Authors

Xiya Chen¹, Zhiying Liu¹, Bi Zhong¹, Mengjie Zhu¹, Han Yao¹, Xiaojie Chen¹, Yongchao Lu¹, Shuyun Wang¹, Yaping Guo²

Affiliations

¹ School of Pharmacy, Henan University, Kaifeng, China.
² Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, China.

PMID: 36412548
DOI: 10.1080/14786419.2022.2148378

Abstract

Eleven 4-phenylcoumarins including three new 4-phenylcoumarins, mesuaferols A-C (1-3), together with eight known 4-phenylcoumarins (4-11) have been isolated from the flowering buds of Mesua ferrea. Their structures were elucidated via UV, IR, HR-ESI-MS, and NMR spectral data. Compound 9 showed moderate cytotoxic activity toward MDA-MB-231, MCF-7, HepG2 and HeLa cell lines with IC₅₀ values of 13.68 ± 1.36 μM, 9.27 ± 1.84 μM, 21.06 ± 1.95 μM, and 7.26 ± 1.68 μM, respectively, and other compounds showed weak cytotoxicity.

Keywords: 4-phenylcoumarins; Guttiferae; Mesua ferrea; cytotoxicity.