Characteristics of ginsenoside Rd-induced effects on rat intestinal contractility with irritable bowel syndrome

Fangfei Liu; Yating Shen; Jiabin Li; Lixia Bi; Xiaoli Ye; Yanhong Li; Du Zhi

doi:10.1080/14786419.2022.2146686

Characteristics of ginsenoside Rd-induced effects on rat intestinal contractility with irritable bowel syndrome

Nat Prod Res. 2023 Aug-Sep;37(18):3152-3157. doi: 10.1080/14786419.2022.2146686. Epub 2022 Nov 22.

Authors

Fangfei Liu¹, Yating Shen², Jiabin Li², Lixia Bi³, Xiaoli Ye⁴, Yanhong Li², Du Zhi²

Affiliations

¹ Department of Pharmacy, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
² Department of Pharmacy, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.
³ Department of Obstetrics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
⁴ Department of Medical Administration, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.

PMID: 36412543
DOI: 10.1080/14786419.2022.2146686

Abstract

Irritable bowel syndrome (IBS) is a very common refractory disease. Its exact pathophysiological mechanism is still unclear. Despite the availability of plentiful drugs to control IBS, most patients do not respond well. Ginsenoside Rd is one of the major active components of Panax ginseng, which has been verified to produce various pharmacological actions. However, the role of ginsenoside Rd in modulating smooth muscle contractility is still undefined. The aim of this study is to investigate the effects of ginsenoside Rd on intestinal contractility and related mechanisms in IBS.

Keywords: Ginsenoside Rd; IBS; MLCK; p-MLC20.