Spinal Dural Arteriovenous Fistula in a Young Male Associated with Craniospinal Leptomeningeal Spread of a Treated High-Grade Glioma

Neurol India. 2022 Sep-Oct;70(Supplement):S326-S330. doi: 10.4103/0028-3886.360935.

Abstract

Spinal dural arteriovenous fistulae (SDAVF) are most commonly idiopathic in origin but may occasionally be seen secondary to surgery, trauma, or inflammation. We report a case of 27-year-old male who came with features of a myelopathy. He was found to have an SDAVF associated with leptomeningeal spread (LMS) of a previously treated high-grade cerebral glioma. Hemorrhagic presentation of gliomas, as in this case, is due to upregulation of vascular endothelial growth factor, which has also been postulated to play a role in the development of SDAVFs. This may suggest a possible mechanism of induction of secondary SDAVFs associated with such tumors. While the coexistence of intracranial neoplasms with vascular malformations has been reported previously, this is the first case report of LMS of a high-grade glioma associated with an SDAVF.

Keywords: Dural arteriovenous fistula; glioblastoma; glioma; leptomeningeal spread; spinal vascular malformation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Neoplasms* / complications
  • Brain Neoplasms* / genetics
  • Brain Neoplasms* / pathology
  • Brain Neoplasms* / therapy
  • Central Nervous System Vascular Malformations* / etiology
  • Central Nervous System Vascular Malformations* / physiopathology
  • Dura Mater
  • Glioma* / complications
  • Glioma* / genetics
  • Glioma* / physiopathology
  • Glioma* / secondary
  • Glioma* / therapy
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Meningeal Carcinomatosis* / complications
  • Meningeal Carcinomatosis* / physiopathology
  • Meningeal Carcinomatosis* / secondary
  • Neoplasm Invasiveness
  • Spinal Cord Diseases* / etiology
  • Spinal Cord Diseases* / genetics
  • Spinal Cord Diseases* / physiopathology
  • Vascular Endothelial Growth Factor A / genetics
  • Vascular Endothelial Growth Factor A / physiology

Substances

  • Vascular Endothelial Growth Factor A