Fatty foods and the risk of bladder cancer: A case-control study

Chunying Teng; Sicong Zheng; Wenting Wan; Lihua Liu; Siwen Yu; Muyang Cao; Weihong Lu; Yujuan Shan

doi:10.1016/j.nut.2022.111868

Fatty foods and the risk of bladder cancer: A case-control study

Nutrition. 2023 Feb:106:111868. doi: 10.1016/j.nut.2022.111868. Epub 2022 Oct 17.

Authors

Chunying Teng¹, Sicong Zheng², Wenting Wan², Lihua Liu², Siwen Yu³, Muyang Cao³, Weihong Lu⁴, Yujuan Shan⁵

Affiliations

¹ Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China; School of Public Health and Management, Wenzhou Medical University, Wenzhou, China.
² School of Public Health and Management, Wenzhou Medical University, Wenzhou, China.
³ Department of Urology, Harbin Medical University Cancer Hospital, Harbin, China.
⁴ Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China. Electronic address: lwh@hit.edu.cn.
⁵ School of Public Health and Management, Wenzhou Medical University, Wenzhou, China. Electronic address: yujuanshan@wmu.edu.cn.

PMID: 36411185
DOI: 10.1016/j.nut.2022.111868

Abstract

Objective: The aim of this study was to explore the association between dietary fatty foods and the risk for bladder cancer.

Methods: Patients newly diagnosed with bladder cancer (n = 113) and 292 controls were recruited. A food frequency questionnaire (FFQ) was used to investigate the food intake within 1 y. Multivariate logistic regression model was used to estimated odds ratio (OR) between different types of fatty food consumption and bladder cancer.

Results: The consumption of soybean oil, the largest proportion of cooking oil, in both groups were much higher than the Chinese recommended dietary intake, especially in the control group. Higher intake of red meat was also observed in bladder cancer cases, although lower intakes of marine fish, egg, milk, and dairy products and nuts were observed in controls. After adjusting for potential confounders, the intakes of marine fish and milk and dairy products were negatively correlated with bladder cancer, with the adjusted OR of 0.28 (95% confidence interval [CI], 0.15-0.55) and 0.36 (95% CI, 0.19-0.69). Total nuts were related to a 76% reduction in bladder cancer risk (OR, 0.24; 95% CI, 0.12-0.48). There was clear and positive association between soybean oil and bladder cancer risk with OR of 3.47 (95 % CI, 1.69-7.14). In stratified analyses by sex and smoking status, the relationship was similar for most results, except for milk and dairy products. The negative correlation between milk and dairy products and bladder cancer risk was only found in men; and milk and dairy products and bladder cancer risk were irrelevant by smoking status. No significant association was found between the intakes of other foods and bladder cancer risk.

Conclusions: Intake of nuts and marine fish may be beneficial for the prevention of bladder cancer. The protective effect of milk and dairy products was only found in men with bladder cancer. High soybean oil intake was a risk factor for bladder cancer.

Keywords: Bladder cancer; Case–control study; Fatty food.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Case-Control Studies
Dairy Products
Diet / adverse effects
Milk
Risk Factors
Soybean Oil*
Urinary Bladder Neoplasms* / epidemiology
Urinary Bladder Neoplasms* / etiology
Urinary Bladder Neoplasms* / prevention & control

Substances

Soybean Oil