Bcl11b and Atoh8 Coordinate Cellular Plasticity for Reprogramming and Transformation

Mo-Fan Huang; Rachel Shoemaker; Dung-Fang Lee

doi:10.1089/cell.2022.0128

Bcl11b and Atoh8 Coordinate Cellular Plasticity for Reprogramming and Transformation

Cell Reprogram. 2022 Dec;24(6):324-326. doi: 10.1089/cell.2022.0128. Epub 2022 Nov 21.

Authors

Mo-Fan Huang^{1

2}, Rachel Shoemaker^{1

3}, Dung-Fang Lee^{1

2

4

5}

Affiliations

¹ Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
² UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
³ Department of Biosciences, Weiss School of Natural Sciences, Rice University, Houston, Texas, USA.
⁴ School of Biomedical Informatics, Center for Precision Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
⁵ Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Abstract

By dissecting and comparing the transcriptional trajectories and epigenomic traits of reprogramming and transforming cells at the single-cell resolution, Huyghe et al discovered Bcl11b and Atoh8, two key transcription factors controlling cell plasticity during pluripotent reprogramming and oncogenic transformation.

Keywords: cellular plasticity; reprogramming; single-cell; transformation.

Publication types

News
Research Support, N.I.H., Extramural

MeSH terms

Cell Plasticity*
Cell Transformation, Neoplastic / genetics
Cellular Reprogramming
Humans
Repressor Proteins
Transcription Factors*
Tumor Suppressor Proteins

Substances

Transcription Factors
Tumor Suppressor Proteins
BCL11B protein, human
Repressor Proteins