Neutrophils: As a Key Bridge between Inflammation and Thrombosis

Pengxiang Xu; Liuyan Xin; Xiaoping Xiao; Yong Huang; Chuanming Lin; Xiaofang Liu; Haiyan Wei; Rong Xu; Yijian Chen

doi:10.1155/2022/1151910

Neutrophils: As a Key Bridge between Inflammation and Thrombosis

Evid Based Complement Alternat Med. 2022 Nov 9:2022:1151910. doi: 10.1155/2022/1151910. eCollection 2022.

Authors

Pengxiang Xu¹, Liuyan Xin¹, Xiaoping Xiao², Yong Huang², Chuanming Lin¹, Xiaofang Liu¹, Haiyan Wei¹, Rong Xu¹, Yijian Chen¹

Affiliations

¹ The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, China.
² Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, Jiangxi, China.

Abstract

Immunothrombosis is a mechanism of defense of the organism against pathogenic microorganisms that increases their recognition, limitation, and clearance and is part of the innate immune defense. Physiological immunothrombosis is beneficial to the body against the invasion of pathogenic microorganisms, but when immunothrombosis is out of control, it is easy to cause thrombotic diseases, thus, causing unpredictable consequences to the body. Neutrophils play a pivotal role in this process. Understanding the mechanism of neutrophils in immune thrombosis and out-of-control is particularly important for the treatment of related thrombotic diseases. In this review, we studied the role of neutrophils in immune thrombosis and each link out of control (including endothelial cell dysfunction; activation of platelets; activation of coagulation factor; inhibition of the anticoagulation system; and inhibition of the fibrinolysis system).

Publication types

Review