Influence of aging on mechanical properties of the femoral neck using an inverse method

Benjamin Voumard; Pia Stefanek; Michael Pretterklieber; Dieter Pahr; Philippe Zysset

doi:10.1016/j.bonr.2022.101638

Influence of aging on mechanical properties of the femoral neck using an inverse method

Bone Rep. 2022 Nov 14:17:101638. doi: 10.1016/j.bonr.2022.101638. eCollection 2022 Dec.

Authors

Benjamin Voumard¹, Pia Stefanek², Michael Pretterklieber³, Dieter Pahr², Philippe Zysset¹

Affiliations

¹ ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland.
² Institute of Lightweight Design and Structural Biomechanics, Vienna University of Technology, Austria.
³ Gottfried Schatz Research Center, Division of Macroscopic and Clinical Anatomy, Medical University of Graz, Austria.

Abstract

Today, we are facing rapid aging of the world population, which increases the incidence of hip fractures. The gold standard of bone strength assessment in the laboratory is micro-computed finite element analysis (μFEA) based on micro-computed tomography (μCT) images. In clinics, the standard method to assess bone fracture risk is based on areal bone mineral density (aBMD), measured by dual-energy X-ray absorptiometry (DXA). In addition, homogenized finite element analysis (hFEA) constructed from quantitative computed tomography reconstructions (QCT) predicts clinical bone strength more accurately than DXA. Despite considerable evidence of degradation of bone material properties with age, in the past fifty years of finite element analysis to predict bone strength, bone material parameters remained independent of age. This study aims to assess the influence of age on apparent modulus, yield stress, and strength predictions of the human femoral neck made by laboratory-available bone volume fraction (BV/TV) and μFEA; and by clinically available DXA and hFEA. Using an inverse method, we test the hypothesis that FEA material parameters are independent of age. Eighty-six human femora were scanned with DXA (aBMD) and with QCT. The femoral necks were extracted and scanned at 16 μm resolution with μCT. The grayscale images were downscaled to 32 μm and 65 μm for linear and non-linear analyses, respectively, and segmented. The μFE solver ParOSolNL (non-linear) and a standard hFEA method were applied to the neck sections with the same material properties for all samples to compute apparent modulus, yield stress, and strength. Laboratory-available BV/TV was a good predictor of apparent modulus (R² = 0.76), almost as good as μFEA (R² = 0.79). However, yield stress and strength were better predicted by μFEA (R² = 0.92, R² = 0.86, resp.) than BV/TV (R² = 0.76, R² = 0.76, resp.). For clinically available variables, prediction of apparent modulus was better with hFEA than aBMD (R² = 0.67, R² = 0.58, resp.). hFEA outperformed aBMD for predictions of yield stress (R² = 0.63 vs R² = 0.34 for female and R² = 0.55 for male) and strength (R² = 0.48 vs R² = 0.33 for female and R² = 0.15 for male). The inclusion of age did not improve the multiple linear models for apparent modulus, yield stress, and strength. The resolution of the μFE meshes seems to account for most morphological changes induced by aging. The errors between the simulation and the experiment for apparent modulus, yield stress, and strength were age-independent, suggesting no rationale for correcting tissue material parameters in the current FE analysis of the aging femoral neck.

Keywords: Bone aging; Bone mechanical properties; Bone strength prediction; DXA; Femoral neck; Homogenized finite element; Micro finite element.