Engineering white blood cell membrane-camouflaged nanocarriers for inflammation-related therapeutics

Wanli Song; Pengfei Jia; Yaping Ren; Junmiao Xue; Bingqian Zhou; Xinkai Xu; Yansheng Shan; Jing Deng; Qihui Zhou

doi:10.1016/j.bioactmat.2022.10.026

Engineering white blood cell membrane-camouflaged nanocarriers for inflammation-related therapeutics

Bioact Mater. 2022 Nov 9:23:80-100. doi: 10.1016/j.bioactmat.2022.10.026. eCollection 2023 May.

Authors

Wanli Song^{1

2

3

4}, Pengfei Jia^{1

3

4}, Yaping Ren^{1

3

4}, Junmiao Xue^{1

3

4}, Bingqian Zhou^{1

3

4}, Xinkai Xu^{1

3

4}, Yansheng Shan^{1

3

4}, Jing Deng^{1

3

4}, Qihui Zhou^{1

2

3

4

5

6}

Affiliations

¹ Department of Stomatology, Institute for Translational Medicine, The Afﬁliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, China.
² Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China.
³ Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, 266003, Shandong, China.
⁴ School of Stomatology, Qingdao University, Qingdao, 266003, China.
⁵ Tianjin Enterprise Key Laboratory for Application Research of Hyaluronic Acid, Tianjin, 300038, China.
⁶ School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, 266071, China.

Abstract

White blood cells (WBCs) play essential roles against inflammatory disorders, bacterial infections, and cancers. Inspired by nature, WBC membrane-camouflaged nanocarriers (WBC-NCs) have been developed to mimic the "dynamic" functions of WBCs, such as transendothelial migration, adhesion to injured blood vessels, etc, which make them promising for diverse medical applications. WBC-NCs inherit the cell membrane antigens of WBCs, while still exhibiting the robust inflammation-related therapeutic potential of synthetic nanocarriers with excellent (bio)physicochemical performance. This review summarizes the proposed concept of cell membrane engineering, which utilizes physical engineering, chemical modification, and biological functionalization technologies to endow the natural cell membrane with abundant functionalities. In addition, it highlights the recent progress and applications of WBC-NCs for inflammation targeting, biological neutralization, and immune modulation. Finally, the challenges and opportunities in realizing the full potential of WBC-NCs for the manipulation of inflammation-related therapeutics are discussed.

Keywords: Biological neutralization; Immune modulation; Inflammation targeting; White blood cell membrane-camouflaged nanocarriers.

Publication types

Review