Quantitative NMR Interpretation without Reference

Priscila Ivo Rubim de Santana; Joyce Sobreiro Francisco Diz de Almeida; Tanos Celmar Costa França; Jochen Junker

doi:10.1155/2022/7490691

Quantitative NMR Interpretation without Reference

J Anal Methods Chem. 2022 Nov 10:2022:7490691. doi: 10.1155/2022/7490691. eCollection 2022.

Authors

Priscila Ivo Rubim de Santana^{1

2}, Joyce Sobreiro Francisco Diz de Almeida¹, Tanos Celmar Costa França^{1

3}, Jochen Junker²

Affiliations

¹ Laboratory of Molecular Modeling Applied to Chemical em Biological Defense (LMCBD), Military Institute of Engineering, Rio de Janeiro 22290-270, Brazil.
² Oswaldo Cruz Foundation, CDTS, Av. Brasil 4365, Rio de Janeiro 21040-900, Brazil.
³ Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.

Abstract

As has been documented numerous times over the years, nuclear magnetic resonance (NMR) experiments are intrinsically quantitative. Still, quantitative NMR methods have not been widely adopted or largely introduced into pharmacopoeias. Here, we describe the quantitative interpretation of the 1D proton NMR experiment using only absolute signal intensities with the variation of common experimental parameters and their application.