Inhibition of Angiogenesis by MiR-524-5p through Suppression of AKT and ERK Activation by Targeting CXCR7 in Colon Cancer Cells

Xiang Li; Zitao Li; Caijuan Li; Yi Fang; Gaosen Zhang; Yudie Yan; Xiaodi Zhao; Xiaole Song; Zhen Zhang

doi:10.1155/2022/7224840

Inhibition of Angiogenesis by MiR-524-5p through Suppression of AKT and ERK Activation by Targeting CXCR7 in Colon Cancer Cells

J Oncol. 2022 Nov 10:2022:7224840. doi: 10.1155/2022/7224840. eCollection 2022.

Authors

Xiang Li¹, Zitao Li², Caijuan Li³, Yi Fang¹, Gaosen Zhang¹, Yudie Yan¹, Xiaodi Zhao¹, Xiaole Song¹, Zhen Zhang¹

Affiliations

¹ Department of Ultrasonic Diagnosis, The First Hospital of China Medical University, 155 Nanjing North Street, Shenyang, Liaoning, China.
² Department of Orthopedic Surgery, Hongqi Hospital, Mudanjiang Medical University, 5 Tongxiang Road, Mudanjiang, Heilongjiang, China.
³ Department of Ultrasound, Hongqi Hospital, Mudanjiang Medical University, 5 Tongxiang Road, Mudanjiang, Heilongjiang 157011, China.

Abstract

Increasing evidence shows that alterations in microRNA (miRNA) expression are involved in the occurrence and development of various malignant tumors, including colon cancer. MiRNA-524-5p has been reported to have anticancer activity in colon cancer. This study explored the influence of the miRNA-524-5p/CXCR7 axis on angiogenesis using colon cancer cells and further studied the mechanisms involved. We found that changing the expression of miRNA-524-5p can affect colonic proliferation, migration, and angiogenesis. Furthermore, angiogenesis induced by miRNA-524-5p overexpression was reversed by overexpression of CXCR7 in HT-29 cells, while the opposite was observed in Caco-2 cells. Furthermore, miRNA-524-5p inhibited the activation of AKT and ERK signaling by targeting CXCR7. Overall, our results indicated that the miRNA-524-5p/CXCR7 axis regulated angiogenesis in colon cancer cells through the AKT and ERK pathways.