Diastolic function and cardiovascular risk among patients with severe obesity referred to a lifestyle-program - a pilot study

Line M Oldervoll; Rolf Gjestad; Christina Hilmarsen C; Anders Ose; Lisbeth Gullikstad; Ulrik Wisløff; Baard Kulseng; Jostein Grimsmo

doi:10.1080/14017431.2022.2146185

Diastolic function and cardiovascular risk among patients with severe obesity referred to a lifestyle-program - a pilot study

Scand Cardiovasc J. 2023 Dec;57(1):8-16. doi: 10.1080/14017431.2022.2146185.

Authors

Line M Oldervoll^{1

2}, Rolf Gjestad¹, Christina Hilmarsen C³, Anders Ose³, Lisbeth Gullikstad³, Ulrik Wisløff^{4

5}, Baard Kulseng⁶, Jostein Grimsmo⁷

Affiliations

¹ Faculty of Psychology, Centre for Crisis Psychology, University of Bergen, Bergen, Norway.
² Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, NTNU, Trondheim, Norway.
³ Unicare Røros Rehabilitation, Røros, Norway.
⁴ Faculty of Medicine and Health Sciences, Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway.
⁵ School of Human Movement and Nutrition Science, University of Queensland, Queensland, Australia.
⁶ Centre for Obesity Research, St. Olavs Hospital, Trondheim, Norway.
⁷ Department of Cardiac Rehabilitation, LHL (National Organization for Heart and Lung Diseases) Hospital Gardermoen, Jessheim, Norway.

PMID: 36404730
DOI: 10.1080/14017431.2022.2146185

Abstract

Objectives. Severe obesity is associated with a high risk of comorbidities and alterations of cardiac structure and function. The primary aim of the study was to investigate the proportion of diastolic dysfunction (DD) at baseline, and changes in cardiac function from baseline (T1) to 6 months follow-up (T2) among participants with severe obesity attending a lifestyle-intervention. The secondary aim was to explore changes in body mass index (BMI), physical fitness (VO_2peak) and cardiovascular risk from T1 to T2 and 12 months follow-up (T3).Design. This was an open single-site prospective observational study. Patients were recruited from an obesity clinic to a lifestyle-intervention consisting of three 3-weeks intermittent stays over 12-months period. Echocardiography was performed at T1 and T2 and BMI, VO_2peak and cardiovascular risk measured at T1, T2 and T3.Results. Fifty-six patients were included (mean age 45.1 years; BMI 41.9). Six of 52 patients (12%) had grade 1 DD at T1, while five subjects had DD at T2. E/A ratio (11%, p = .005) and mitral deceleration time (9%, p = .014) were improved at T2. A reduction in BMI (-1.8, p < .001) and improvement in VO_2peak (1.6 mL/kg min, p = .026) were assessed at T2 and this improvement persisted at T3. The total cardiovascular risk score was not significantly changed.Conclusion. The patients with severe obesity had low prevalence of DD. For all participants, an improvement in diastolic parameters, and an important initial weight loss was observed.Clinical Trial number: NCT02826122.

Keywords: Severe obesity; cardiovascular risk; left ventricular diastolic function; life-style intervention.

Publication types

Observational Study

MeSH terms

Cardiovascular Diseases* / diagnosis
Cardiovascular Diseases* / epidemiology
Cardiovascular Diseases* / prevention & control
Heart Disease Risk Factors
Humans
Life Style
Middle Aged
Obesity, Morbid* / complications
Obesity, Morbid* / diagnosis
Obesity, Morbid* / therapy
Pilot Projects
Risk Factors

Associated data

ClinicalTrials.gov/NCT02826122