The potent role of Src kinase-regulating glucose metabolism in cancer

Wenjun Shao; Li Liu; Fuxiang Zheng; Yanmin Ma; Ji Zhang

doi:10.1016/j.bcp.2022.115333

The potent role of Src kinase-regulating glucose metabolism in cancer

Biochem Pharmacol. 2022 Dec:206:115333. doi: 10.1016/j.bcp.2022.115333. Epub 2022 Oct 29.

Authors

Wenjun Shao¹, Li Liu¹, Fuxiang Zheng², Yanmin Ma¹, Ji Zhang³

Affiliations

¹ The First Affiliated Hospital, Department of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
² Department of Clinical Laboratory, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, Guangdong, China.
³ The First Affiliated Hospital, Department of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; Department of Clinical Laboratory, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, Guangdong, China. Electronic address: jizhang@fsyy.usc.edu.cn.

PMID: 36404485
DOI: 10.1016/j.bcp.2022.115333

Abstract

Src kinase is a membrane-related nonreceptor tyrosine kinase that plays an essential role in cell growth, division, migration, and survival signaling pathways. In addition, it regulates glucose metabolism in cancer cells through different mechanisms, such as directly regulating glucose metabolism related enzymes and glucose transporters or indirectly regulating transcription factors and signal transduction pathways. In this review, we clarify the role of Src kinase in regulating glucose metabolism in cancer cells, and partially explain the pathogenesis of malignant tumors. We also discuss that further understanding and study of the role of Src kinase in glucose metabolism will provide a potential therapeutic window for cancer treatment.

Keywords: Cancer; Glucose metabolism; Src kinase; Targeted therapy; Warburg effect.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrate Metabolism
Glucose
Humans
Neoplasms* / drug therapy
Protein-Tyrosine Kinases
src-Family Kinases*

Substances

src-Family Kinases
Protein-Tyrosine Kinases
Glucose