Neuromuscular mechanisms of motor adaptation to repeated gait-slip perturbations in older adults

Abstract

Individuals can rapidly develop adaptive skills for fall prevention after their exposure to the repeated-slip paradigm. However, the changes in neuromuscular control contributing to such motor adaptation remain unclear. This study investigated changes in neuromuscular control across different stages of slip-adaptation by examining muscle synergies during slip training. Electromyography signals during 24 repeated slip trials in gait were collected for 30 healthy older adults. Muscle synergies in no-adaptation (novel slip), early-adaptation (slip 6 to 8), and late-adaptation trials (slip 22 to 24) were extracted. The similarity between the recruited muscle synergies in these different phases was subsequently analyzed. Results showed that participants made significant improvements in their balance outcomes from novel slips to adapted slips. Correspondingly, there was a significant increase in the muscle synergy numbers from no-adaptation slips to the adapted slips. The participants retained the majority of muscle synergies (5 out of 7) used in novel slips post adaptation. A few new patterns (n = 8) of muscle synergies presented in the early-adaptation stage to compensate for motor errors due to external perturbation. In the late-adaptation stage, only 2 out of these 8 new synergies were retained. Our findings indicated that the central nervous system could generate new muscle synergies through fractionating or modifying the pre-existing synergies in the early-adaptation phase, and these synergies produce motor strategies that could effectively assist in recovery from the slip perturbation. During the late-adaptation phase, the redundant synergies generated in the early-adaptation phase get eliminated as the adaptation process progresses with repeated exposure to the slips, which further consolidates the slip adaptation. Our findings improved the understanding of the key muscle synergies involved in preventing backward balance loss and how neuromuscular responses adapt through repeated slip training, which might be helpful to design synergy-based interventions for fall prevention.