Immunopathogenesis, Diagnosis, and Treatment of Multiple Sclerosis: A Clinical Update

Carlos A Pérez; Fernando X Cuascut; George J Hutton

doi:10.1016/j.ncl.2022.05.004

Immunopathogenesis, Diagnosis, and Treatment of Multiple Sclerosis: A Clinical Update

Neurol Clin. 2023 Feb;41(1):87-106. doi: 10.1016/j.ncl.2022.05.004. Epub 2022 Oct 31.

Authors

Carlos A Pérez¹, Fernando X Cuascut², George J Hutton²

Affiliations

¹ Department of Neurology, Maxine Mesinger Multiple Sclerosis Comprehensive Care Center, 7200 Cambridge Street, Suite 9A, Houston, TX, USA. Electronic address: Carlos.Perez@bcm.edu.
² Department of Neurology, Maxine Mesinger Multiple Sclerosis Comprehensive Care Center, 7200 Cambridge Street, Suite 9A, Houston, TX, USA.

PMID: 36400561
DOI: 10.1016/j.ncl.2022.05.004

Abstract

Multiple sclerosis (MS) is the most prevalent nontraumatic disabling neurologic condition among young adults worldwide. The diagnosis and management of MS is complex. The goal of this review is to provide an updated and practical approach to the diagnosis and treatment approaches in MS, emphasizing current understanding of immunopathogenesis, recent advances, and future directions, for both MS and non-MS clinicians.

Keywords: Central nervous system; Demyelination; Diagnosis; Multiple sclerosis; Treatment.

Publication types

Review

MeSH terms

Humans
Multiple Sclerosis* / drug therapy
Multiple Sclerosis* / therapy
Young Adult