Chronic Pain: Prevalence and Management

Christopher P Carroll; Amanda M Brandow

doi:10.1016/j.hoc.2022.06.009

Chronic Pain: Prevalence and Management

Hematol Oncol Clin North Am. 2022 Dec;36(6):1151-1165. doi: 10.1016/j.hoc.2022.06.009.

Authors

Christopher P Carroll¹, Amanda M Brandow²

Affiliations

¹ Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Osler 320, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address: ccarrol1@jhmi.edu.
² Section of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

PMID: 36400536
DOI: 10.1016/j.hoc.2022.06.009

Abstract

Chronic pain is a distinct complication that profoundly affects the lives of individuals with sickle cell disease (SCD). Chronic SCD pain emerges with increasing age and is very prevalent in adults. The pathophysiology of chronic SCD pain is likely distinct from acute SCD pain and therefore needs a different treatment approach. Clinical trials evaluating the treatment of chronic SCD pain are lacking and treatment currently relies on evidence from other chronic pain conditions. Continued investigations into the underlying causes of chronic SCD pain are needed, and clinical trials focused on chronic pain therapy are imperative.

Keywords: Chronic pain; Nonpharmacologic pain treatment; Opioid; Sickle cell disease.

Publication types

Review

MeSH terms

Adult
Anemia, Sickle Cell* / complications
Anemia, Sickle Cell* / epidemiology
Anemia, Sickle Cell* / therapy
Chronic Pain* / epidemiology
Chronic Pain* / etiology
Chronic Pain* / therapy
Humans
Pain Management
Prevalence